UDP-2,3-diacylglucosamine diphosphatase
UDP-2,3-diacylglucosamine diphosphatase (EC 3.6.1.54, UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine pyrophosphatase, ybbF (gene), lpxH (gene)) is an enzyme with systematic name UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate phosphohydrolase.[1][2] This enzyme catalyses the following chemical reaction
- UDP-2,3-bis[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H2O 2,3-bis[(3R)-3-hydroxymyristoyl]-beta-D-glucosaminyl 1-phosphate + UMP
| UDP-2,3-diacylglucosamine diphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.6.1.54 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme catalyses a step in the biosynthesis of lipid A.
References
- Babinski KJ, Ribeiro AA, Raetz CR (July 2002). "The Escherichia coli gene encoding the UDP-2,3-diacylglucosamine pyrophosphatase of lipid A biosynthesis". The Journal of Biological Chemistry. 277 (29): 25937–46. doi:10.1074/jbc.m204067200. PMID 12000770.
- Babinski KJ, Kanjilal SJ, Raetz CR (July 2002). "Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene". The Journal of Biological Chemistry. 277 (29): 25947–56. doi:10.1074/jbc.m204068200. PMID 12000771.
External links
- UDP-2,3-diacylglucosamine+diphosphatase at the US National Library of Medicine Medical Subject Headings (MeSH)
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