UCN3

Urocortin-3 is a protein that in humans is encoded by the UCN3 gene.[5][6] It belongs to the corticotropin-releasing hormone family.[7]

UCN3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RMH, 3N93
Identifiers
Aliases	UCN3, SCP, SPC, UCNIII, urocortin 3
External IDs	OMIM: 605901 MGI: 1932970 HomoloGene: 49959 GeneCards: UCN3
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.1 Start 5,364,966 bp[1] End 5,374,692 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A1 Start 3,940,688 bp[2] End 3,945,349 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor binding • corticotropin-releasing hormone receptor 2 binding • hormone activity • corticotropin-releasing hormone receptor binding Cellular component • neuron projection • varicosity • axon terminus • axon • extracellular region • extracellular • intracellular Biological process • digestion • response to stress • cellular response to nutrient levels • positive regulation of insulin secretion • response to immobilization stress • response to glucose • response to starvation • cellular response to hypoxia • positive regulation of membrane potential • response to corticosterone • regulation of receptor activity • adenylate cyclase-activating G-protein coupled receptor signaling pathway • hormone-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114131	83428
Ensembl	ENSG00000178473	ENSMUSG00000044988
UniProt	Q969E3	Q924A4
RefSeq (mRNA)	NM_053049	NM_031250
RefSeq (protein)	NP_444277	NP_112540
Location (UCSC)	Chr 10: 5.36 – 5.37 Mb	Chr 13: 3.94 – 3.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors.

In the brain it may be responsible for the effects of stress on appetite. It is also expressed by beta cells in the pancreas and is co-released with insulin to promote somatostatin release from neighboring delta cells, which provides negative feedback on insulin secretion.[8] In spite of the gene family name similarity, the product of this gene has no sequence similarity to Urotensin-II.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000178473 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044988 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W, Bilezikjian L, Rivier J, Sawchenko PE, Vale WW (Jun 2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMC 34709. PMID 11416224.
6. "Entrez Gene: UCN3 urocortin 3 (stresscopin)".
7. Zhang X, Liu Y, Qi J, Tian Z, Tang N, Chen D, Li Z (2019). "Progress in understanding the roles of Urocortin3 (UCN3) in the control of appetite from studies using animal models". Peptides. 121: 170124. doi:10.1016/j.peptides.2019.170124. PMID 31415798. S2CID 199544428.CS1 maint: uses authors parameter (link)
8. van der Meulen T, Donaldson CJ, Cáceres E, Hunter AE, Cowing-Zitron C, Pound LD, Adams MW, Zembrzycki A, Grove KL, Huising MO (Jul 2015). "Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion". Nature Medicine. 21 (7): 769–76. doi:10.1038/nm.3872. PMC 4496282. PMID 26076035.

Further reading

• Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM (Mar 2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacological Reviews. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID 12615952. S2CID 1572317.
• Florio P, Torres PB, Torricelli M, Toti P, Vale W, Petraglia F (Dec 2006). "Human endometrium expresses urocortin II and III messenger RNA and peptides". Fertility and Sterility. 86 (6): 1766–70. doi:10.1016/j.fertnstert.2006.05.041. PMID 17074339.
• Imperatore A, Florio P, Torres PB, Torricelli M, Galleri L, Toti P, Occhini R, Picciolini E, Vale W, Petraglia F (Jul 2006). "Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes". American Journal of Obstetrics and Gynecology. 195 (1): 288–95. doi:10.1016/j.ajog.2005.12.048. PMID 16626608.
• Saruta M, Takahashi K, Suzuki T, Fukuda T, Torii A, Sasano H (Jul 2005). "Urocortin 3/stresscopin in human colon: possible modulators of gastrointestinal function during stressful conditions". Peptides. 26 (7): 1196–206. doi:10.1016/j.peptides.2005.01.014. PMID 15949638. S2CID 23604531.
• Chang CL, Hsu SY (Oct 2004). "Ancient evolution of stress-regulating peptides in vertebrates". Peptides. 25 (10): 1681–8. doi:10.1016/j.peptides.2004.05.022. PMID 15476935. S2CID 25716793.
• Takahashi K, Totsune K, Murakami O, Saruta M, Nakabayashi M, Suzuki T, Sasano H, Shibahara S (Apr 2004). "Expression of urocortin III/stresscopin in human heart and kidney". The Journal of Clinical Endocrinology and Metabolism. 89 (4): 1897–903. doi:10.1210/jc.2003-031663. PMID 15070962.
• Seres J, Bornstein SR, Seres P, Willenberg HS, Schulte KM, Scherbaum WA, Ehrhart-Bornstein M (Feb 2004). "Corticotropin-releasing hormone system in human adipose tissue". The Journal of Clinical Endocrinology and Metabolism. 89 (2): 965–70. doi:10.1210/jc.2003-031299. PMID 14764822.
• Chanalaris A, Lawrence KM, Stephanou A, Knight RD, Hsu SY, Hsueh AJ, Latchman DS (Oct 2003). "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes". Journal of Molecular and Cellular Cardiology. 35 (10): 1295–305. doi:10.1016/S0022-2828(03)00244-X. PMID 14519439.
• Hsu SY, Hsueh AJ (May 2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nature Medicine. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063. S2CID 22916906.