UBXD5

UBX domain-containing protein 11 is a protein that in humans is encoded by the UBXN11 gene.[5][6]

UBXN11
Identifiers
Aliases	UBXN11, COA-1, SOC, SOCI, UBXD5, PP2243, UBX domain protein 11
External IDs	OMIM: 609151 MGI: 1914836 HomoloGene: 12159 GeneCards: UBXN11
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 26,281,328 bp[1] End 26,318,363 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 66.5 cM Start 134,102,570 bp[2] End 134,127,593 bp[2]
Gene ontology Molecular function • ubiquitin binding • GO:0001948 protein binding Cellular component • cytoplasm • cytoskeleton Biological process • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	91544	67586
Ensembl	ENSG00000158062	ENSMUSG00000012126
UniProt	Q5T124	Q9D572
RefSeq (mRNA)	NM_183008 NM_001077262 NM_145345	NM_026257
RefSeq (protein)	NP_001070730 NP_663320 NP_892120	NP_080533
Location (UCSC)	Chr 1: 26.28 – 26.32 Mb	Chr 4: 134.1 – 134.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymorphic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

UBXD5 has been shown to interact with Rnd1,[5] Rnd2[5] and Rnd3.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000158062 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000012126 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Katoh H, Harada A, Mori K, Negishi M (Apr 2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Mol. Cell. Biol. 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. PMC 133765. PMID 11940653.
6. "Entrez Gene: UBXD5 UBX domain containing 5".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Maccalli C, Li YF, El-Gamil M, Rosenberg SA, Robbins PF (2003). "Identification of a colorectal tumor-associated antigen (COA-1) recognized by CD4(+) T lymphocytes". Cancer Res. 63 (20): 6735–43. PMC 2275323. PMID 14583468.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Tateiwa K, Katoh H, Negishi M (2005). "Socius, a novel binding partner of Galpha12/13, promotes the Galpha12-induced RhoA activation". Biochem. Biophys. Res. Commun. 337 (2): 615–20. doi:10.1016/j.bbrc.2005.09.097. PMID 16202387.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.