Tissue selectivity

Tissue selectivity is a topic in distribution (pharmacology) and property of some drugs. It refers to when a drug occurs in disproportionate concentrations and/or has disproportionate effects in specific tissues relative to other tissues.[1] An example of such drugs are selective estrogen receptor modulators (SERM) like tamoxifen, which show estrogenic effects in some tissues and antiestrogenic effects in other tissues. Another example is peripherally-selective drugs, which do not cross the blood-brain-barrier into the central nervous system and hence are tissue-selective for the periphery.

References
  1. Zweten (5 September 1997). Antihypertensive Drugs. CRC Press. p. 345. ISBN 9789057021220. The term “tissue selectivity” is used for an agent showing varying degrees of potency between tissues, with a preferential action in a given one.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.