Tetrahydrocolumbamine 2-O-methyltransferase
In enzymology, a tetrahydrocolumbamine 2-O-methyltransferase (EC 2.1.1.89) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine S-adenosyl-L-homocysteine + tetrahydropalmatine
| tetrahydrocolumbamine 2-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.89 | ||||||||
| CAS number | 93792-09-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl methionine and 5,8,13,13a-tetrahydrocolumbamine, whereas its two products are S-adenosylhomocysteine and tetrahydropalmatine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase. This enzyme is also called tetrahydrocolumbamine methyltransferase. This enzyme participates in alkaloid biosynthesis i.
References
- Beecher CW, Kelleher WJ (1984). "Enzymatic study of the late stages of protoberberine alkaloid biosynthesis". Tetrahedron Lett. 25 (41): 4595–4598. doi:10.1016/S0040-4039(01)91208-0.
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