Taxadienone
Taxadienone ((+)-taxa-4(5),11(12)-dien-2-one) is an organic compound and a taxane. The compound is of some academic interest as a potential precursor to Taxol, in important anti-cancer drug, in a commercially viable process.[1] A total synthesis of taxadienone was reported in 2012 together with its conversion to the next Taxol precursor taxadiene.[2] A multigram synthetic method was reported in 2015.[3]
 | |
| Names | |
|---|---|
| IUPAC name
(+)-Taxa-4(5),11(12)-dien-2-one | |
| Identifiers | |
3D model (JSmol) |
|
| ChemSpider | |
| |
| |
| Properties | |
| C20H30O | |
| Molar mass | 286.459 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
References
- GEN News Highlights Nov 7, 2011 Scientists Develop Scalable Process for Synthesizing Diverse Taxanes http://www.genengnews.com/gen-news-highlights/scientists-develop-scalable-process-for-synthesizing-diverse-taxanes/81245919/
- Scalable enantioselective total synthesis of taxanes Abraham Mendoza, Yoshihiro Ishihara, Phil S. Baran Nature Chemistry 4, 21–25 (2012) doi:10.1038/nchem.1196
- Route Optimization and Synthesis of Taxadienone Sergiy G. Krasutsky, Sheila H. Jacobo, Scott R. Tweedie, Ravi Krishnamoorthy, and Alexander S. Filatov Organic Process Research & Development 2015 19 (1), 284-289 doi:10.1021/op500314c
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.