Tania Watts

Tania H. Watts (born 1957) is a Canadian Immunologist, Professor at the University of Toronto,[1] past President of the Canadian Society for Immunology and from 2009-2019 held the Sanofi Pasteur Chair in Human Immunology at the University of Toronto.[2]

Tania Watts
Alma materUniversity of Alberta
Scientific career
FieldsImmunology
ThesisStructure and assembly of pili isolated from Pseudomonas aeruginosa strains PAK and PAO
Doctoral advisorWilliam Paranchych

Education

Watts studied at the University of Alberta where she obtained her Bachelor and PhD degrees in Biochemistry.[3] Her graduate supervisor was William Paranchych.[2] She was supported during her graduate work by an MRC Studentship.[4]

Scientific career

Watts' graduate research examined the structure and assembly of pili from Pseudomonas aeruginosa.

Her post-doctoral work at Stanford University with Professor Harden McConnell demonstrated the immunological effect of antigen presentation in lipid bilayers and led to her interest in T cells and immunity.[2]

Watts is Professor of Immunology at the University of Toronto.[1] Her group was among the first to provide evidence for CD28-independent co-stimulation.[5] Watts holds the Sanofi Pasteur Chair in Human Immunology at the University of Toronto.[2][6] She is director of the Faculty of Medicine Flow Cytometry facility.[7]

Watts is an active organizer in the Immunology community. She is a founder the Toronto Human Immunology Network, past President (2009-2011) of the Canadian Society for Immunology, and has organized international symposia.[3][2]

Research

Watts used biophysical techniques to study the properties of pili isolated from Pseudomonas aeruginosa strain PAO and PAK for her doctoral work.[4][8]

Watts' post-doctoral research encompassed biochemical methods and the microscopy techniques TIRF (Total Internal Reflection Fluorescence) and FRET (Fluorescence Resonance Energy Transfer). Her work showed that CD4+ T cells could be activated to secrete Interleukin 2 by a lipid bilayer containing MHC II and peptide antigens, and that MHC II, peptide antigens and T-cell Receptor form a ternary complex.[9][10]

Watts' laboratory at the University of Toronto continues her immunology research, with a focus on T cells, adaptive immunity and infectious diseases.[1] Her group examines how different TNF Receptor family members contribute to survival of lymphocytes to control viral infections.[11] Her studies also demonstrate how TNFR activation contributes to inflammation and cancer.[6]

Awards

References
  1. "Tania Watts Faculty Page".
  2. "Hardy Cinader Award" (PDF).
  3. "Tania Watts Bio".
  4. Watts, T. H.; Kay, C. M.; Paranchych, W. (1982). "Dissociation and characterization of pilin isolated from Pseudomonas aeruginosa strains PAK and PAO". Canadian Journal of Biochemistry. 60 (9): 867–872. doi:10.1139/o82-110. ISSN 0008-4018. PMID 6129055.
  5. DeBenedette, M. A.; Shahinian, A.; Mak, T. W.; Watts, T. H. (1997). "Costimulation of CD28- T lymphocytes by 4-1BB ligand". Journal of Immunology. 158 (2): 551–559. ISSN 0022-1767. PMID 8992967.
  6. "University of Toronto professor wins GSK's 2014 Discovery Fast Track Challenge".
  7. "Faculty of Medicine Flow Cytometry Contacts".
  8. Watts, T. H.; Sastry, P. A.; Hodges, R. S.; Paranchych, W. (1983). "Mapping of the antigenic determinants of Pseudomonas aeruginosa PAK polar pili". Infection and Immunity. 42 (1): 113–121. doi:10.1128/IAI.42.1.113-121.1983. ISSN 0019-9567. PMC 264531. PMID 6194112.
  9. Watts, T. H.; Brian, A. A.; Kappler, J. W.; Marrack, P.; McConnell, H. M. (1984). "Antigen presentation by supported planar membranes containing affinity-purified I-Ad". Proceedings of the National Academy of Sciences of the United States of America. 81 (23): 7564–7568. Bibcode:1984PNAS...81.7564W. doi:10.1073/pnas.81.23.7564. ISSN 0027-8424. PMC 392187. PMID 6334313.
  10. Watts, T. H.; Gaub, H. E.; McConnell, H. M. (1986). "T-cell-mediated association of peptide antigen and major histocompatibility complex protein detected by energy transfer in an evanescent wave-field". Nature. 320 (6058): 179–181. Bibcode:1986Natur.320..179W. doi:10.1038/320179a0. ISSN 0028-0836. PMID 2936964.
  11. Chang, Yu-Han; Wang, Kuan Chung; Chu, Kuan-Lun; Clouthier, Derek L.; Tran, Anh T.; Torres Perez, Miguel S.; Zhou, Angela C.; Abdul-Sater, Ali A.; Watts, Tania H. (2017). "Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity". Immunity. 47 (5): 943–958.e9. doi:10.1016/j.immuni.2017.10.014. ISSN 1097-4180. PMID 29150240.
  12. "CSI Investigator Award Recipients".
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