TRIM9

Tripartite motif-containing protein 9 is a protein that in humans is encoded by the TRIM9 gene.[5][6][7]

TRIM9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DB8
Identifiers
Aliases	TRIM9, RNF91, SPRING, tripartite motif containing 9
External IDs	OMIM: 606555 MGI: 2137354 HomoloGene: 9045 GeneCards: TRIM9
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.1 Start 50,975,262 bp[1] End 51,096,061 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 70,244,533 bp[2] End 70,347,614 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • zinc ion binding • GO:0001948 protein binding • protein homodimerization activity • transferase activity • protein domain specific binding • ubiquitin-protein transferase activity • SNARE binding Cellular component • cytoplasm • cytoplasmic vesicle • cell junction • dendrite • cell projection • synapse • cytoskeleton • synaptic vesicle • intracellular • cytosol • presynaptic cytosol Biological process • negative regulation of calcium ion-dependent exocytosis • protein ubiquitination • negative regulation of SNARE complex assembly • synaptic vesicle exocytosis • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114088	94090
Ensembl	ENSG00000100505	ENSMUSG00000021071
UniProt	Q9C026	Q8C7M3
RefSeq (mRNA)	NM_015163 NM_052978	NM_001110202 NM_001110203 NM_001286386 NM_001286387 NM_001286388 NM_053167
RefSeq (protein)	NP_055978 NP_443210	NP_001103672 NP_001103673 NP_001273315 NP_001273316 NP_001273317 NP_444397
Location (UCSC)	Chr 14: 50.98 – 51.1 Mb	Chr 12: 70.24 – 70.35 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms.[7]

Interactions

TRIM9 has been shown to interact with SNAP-25.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000100505 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021071 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
6. Li Y, Chin LS, Weigel C, Li L (Oct 2001). "Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis". J Biol Chem. 276 (44): 40824–33. doi:10.1074/jbc.M106141200. PMID 11524423.
7. "Entrez Gene: TRIM9 tripartite motif-containing 9".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Ohara O, Nagase T, Ishikawa K, et al. (1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins". DNA Res. 4 (1): 53–9. doi:10.1093/dnares/4.1.53. PMID 9179496.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.