TRIM11

Tripartite motif-containing protein 11 is a protein found in humans that is encoded by the TRIM11 gene.[5][6]

TRIM11
Identifiers
Aliases	TRIM11, BIA1, RNF92, tripartite motif containing 11
External IDs	OMIM: 607868 MGI: 2137355 HomoloGene: 14225 GeneCards: TRIM11
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 228,393,673 bp[1] End 228,406,835 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 58,978,093 bp[2] End 58,991,458 bp[2]
Gene ontology Molecular function • ubiquitin-protein transferase activity • zinc ion binding • transcription factor binding • GO:0001948 protein binding • protein domain specific binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • metal ion binding • transferase activity Cellular component • cytoplasm • intracellular • cell nucleus • cytosol Biological process • negative regulation of neurogenesis • innate immune system • negative regulation of transcription, DNA-templated • defense response to virus • protein ubiquitination • negative regulation of viral transcription • negative regulation of viral entry into host cell • positive regulation of viral entry into host cell • negative regulation of viral release from host cell Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81559	94091
Ensembl	ENSG00000154370	ENSMUSG00000020455
UniProt	Q96F44	Q99PQ2
RefSeq (mRNA)	NM_145214	NM_001290988 NM_053168
RefSeq (protein)	NP_660215	NP_001277917 NP_444398
Location (UCSC)	Chr 1: 228.39 – 228.41 Mb	Chr 11: 58.98 – 58.99 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000154370 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020455 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
6. "Entrez Gene: TRIM11 tripartite motif-containing 11".

Further reading

• Ishikawa H, Tachikawa H, Miura Y, Takahashi N (2006). "TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system". FEBS Lett. 580 (20): 4784–92. doi:10.1016/j.febslet.2006.07.066. PMID 16904669.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Cooper ST, Hanson IM (2006). "A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11". BMC Genet. 6: 43. doi:10.1186/1471-2156-6-43. PMC 1208879. PMID 16098226.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Niikura T, Hashimoto Y, Tajima H, et al. (2003). "A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults". Eur. J. Neurosci. 17 (6): 1150–8. doi:10.1046/j.1460-9568.2003.02553.x. PMID 12670303. S2CID 1345339.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.