TOMM70A

Mitochondrial import receptor subunit TOM70 is a protein that in humans is encoded by the TOMM70A gene.[4][5]

TOMM70
Identifiers
Aliases	TOMM70, TOMM70A, Tom70, translocase of outer mitochondrial membrane 70
External IDs	OMIM: 606081 MGI: 106295 HomoloGene: 40112 GeneCards: TOMM70
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q12.2 Start 100,363,431 bp[1] End 100,401,089 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein transmembrane transporter activity • GO:0001948 protein binding Cellular component • mitochondrial outer membrane • extracellular exosome • integral component of membrane • mitochondrial outer membrane translocase complex • membrane • mitochondrion Biological process • macroautophagy • protein targeting to mitochondrion • protein transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9868	28185
Ensembl	ENSG00000154174	ENSMUSG00000022752
UniProt	O94826	Q9CZW5
RefSeq (mRNA)	NM_014820	NM_138599
RefSeq (protein)	NP_055635	NP_613065
Location (UCSC)	Chr 3: 100.36 – 100.4 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. See TIM17A (MIM 605057).[supplied by OMIM][5]

See also

• Mitochondria Outer Membrane Translocase
• TOMM20
• TOMM22
• TOMM40

References

1. GRCh38: Ensembl release 89: ENSG00000154174 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Alvarez-Dolado M, Gonzalez-Moreno M, Valencia A, Zenke M, Bernal J, Munoz A (Dec 1999). "Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions". J Neurochem. 73 (6): 2240–9. doi:10.1046/j.1471-4159.1999.0732240.x. PMID 10582581. S2CID 23008591.
5. "Entrez Gene: TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)".

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Edmonson AM, Mayfield DK, Vervoort V, et al. (2002). "Characterization of a human import component of the mitochondrial outer membrane, TOMM70A". Cell Commun. Adhes. 9 (1): 15–27. doi:10.1080/15419060212186. PMID 12200962.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Young JC, Hoogenraad NJ, Hartl FU (2003). "Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70". Cell. 112 (1): 41–50. doi:10.1016/S0092-8674(02)01250-3. PMID 12526792.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphries AD, Streimann IC, Stojanovski D, et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40". J. Biol. Chem. 280 (12): 11535–43. doi:10.1074/jbc.M413816200. PMID 15644312.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Chou CH, Lee RS, Yang-Yen HF (2006). "An Internal EELD Domain Facilitates Mitochondrial Targeting of Mcl-1 via a Tom70-dependent Pathway". Mol. Biol. Cell. 17 (9): 3952–63. doi:10.1091/mbc.E06-04-0319. PMC 1593170. PMID 16822835.
• Fan AC, Bhangoo MK, Young JC (2006). "Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import". J. Biol. Chem. 281 (44): 33313–24. doi:10.1074/jbc.M605250200. PMID 16968702.