TOB2

Protein Tob2 is a protein that in humans is encoded by the TOB2 gene.[5][6][7]

TOB2
Identifiers
Aliases	TOB2, TOB4, TOBL, TROB2, transducer of ERBB2, 2, APRO5
External IDs	OMIM: 607396 MGI: 1888525 HomoloGene: 9447 GeneCards: TOB2
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 41,433,494 bp[1] End 41,446,801 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 81,848,272 bp[2] End 81,858,796 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • vitamin D receptor binding • GO:0001106 transcription corepressor activity Cellular component • cell nucleus • cytoplasm • cytosol Biological process • positive regulation of ossification • female gamete generation • negative regulation of osteoclast differentiation • regulation of gene expression • negative regulation of cell proliferation • signaling • negative regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10766	57259
Ensembl	ENSG00000183864	ENSMUSG00000048546
UniProt	Q14106	Q9JM55
RefSeq (mRNA)	NM_016272	NM_020507
RefSeq (protein)	NP_057356	NP_065253
Location (UCSC)	Chr 22: 41.43 – 41.45 Mb	Chr 15: 81.85 – 81.86 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM][7]

Interactions

TOB2 has been shown to interact with CNOT7.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000183864 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048546 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (Jan 2000). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.
6. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
7. "Entrez Gene: TOB2 transducer of ERBB2, 2".

Further reading

• Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
• Suzuki T, Matsuda S, Tsuzuku JK, et al. (2001). "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob". Genes Cells. 6 (2): 131–8. doi:10.1046/j.1365-2443.2001.00406.x. PMID 11260258.
• Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMC 5926753. PMID 11429045.
• Sasajima H, Nakagawa K, Yokosawa H (2002). "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system". Eur. J. Biochem. 269 (14): 3596–604. doi:10.1046/j.1432-1033.2002.03052.x. PMID 12135500.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.