TNIP1

TNFAIP3-interacting protein 1 is a protein that in humans is encoded by the TNIP1 gene.[5][6][7]

TNIP1
Identifiers
Aliases	TNIP1, ABIN-1, NAF1, VAN, nip40-1, TNFAIP3 interacting protein 1
External IDs	OMIM: 607714 MGI: 1926194 HomoloGene: 31355 GeneCards: TNIP1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 151,029,945 bp[1] End 151,093,577 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 54,910,785 bp[2] End 54,962,917 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • mitogen-activated protein kinase binding • identical protein binding • polyubiquitin modification-dependent protein binding Cellular component • intracellular • nucleoplasm • cell nucleus • cytosol • cytoplasm Biological process • leukocyte cell-cell adhesion • defense response • glycoprotein biosynthetic process • negative regulation of viral genome replication • modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade • positive regulation of inflammatory response • inflammatory response • protein biosynthesis • negative regulation of ERK1 and ERK2 cascade • MyD88-dependent toll-like receptor signaling pathway • regulation of inflammatory response • negative regulation of I-kappaB kinase/NF-kappaB signaling • protein deubiquitination • positive regulation of transcription from RNA polymerase II promoter • cellular response to lipopolysaccharide • positive regulation of protein deubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10318	57783
Ensembl	ENSG00000145901	ENSMUSG00000020400
UniProt	Q15025	Q9WUU8
RefSeq (mRNA)	NM_001252385 NM_001252386 NM_001252390 NM_001252391 NM_001252392 NM_001252393 NM_001258454 NM_001258455 NM_001258456 NM_006058 NM_001364486 NM_001364487	NM_001199275 NM_001199276 NM_001271455 NM_001271456 NM_021327
RefSeq (protein)	NP_001239314 NP_001239315 NP_001239319 NP_001239320 NP_001239321 NP_001239322 NP_001245383 NP_001245384 NP_001245385 NP_006049 NP_001351415 NP_001351416	NP_001186204 NP_001186205 NP_001258384 NP_001258385 NP_067302
Location (UCSC)	Chr 5: 151.03 – 151.09 Mb	Chr 11: 54.91 – 54.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Association with autoimmune diseases

Genetic variations within the region of the TNIP1 gene have been shown to have association with several autoimmune diseases:

• Systemic Sclerosis;[8]
• Psoriasis;[9]
• Psoriatic arthritis;[10]
• Systemic Lupus Erythematosus[11][12]

Interactions

TNIP1 contains multiple amino acid sites that are phosphorylated and ubiquitinated,[13] and has been shown to interact with TNFAIP3,[14] MAP3K1,[15] and MAPK1.[16]

References

1. GRCh38: Ensembl release 89: ENSG00000145901 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020400 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fukushi M, Dixon J, Kimura T, Tsurutani N, Dixon MJ, Yamamoto N (Jan 1999). "Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression". FEBS Letters. 442 (1): 83–8. doi:10.1016/S0014-5793(98)01631-7. PMID 9923610. S2CID 86298611.
6. Gupta K, Ott D, Hope TJ, Siliciano RF, Boeke JD (Dec 2000). "A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions". Journal of Virology. 74 (24): 11811–24. doi:10.1128/JVI.74.24.11811-11824.2000. PMC 112464. PMID 11090181.
7. "Entrez Gene: TNIP1 TNFAIP3 interacting protein 1".
8. Allanore Y, Saad M, Dieudé P, Avouac J, Distler JH, Amouyel P, et al. (Jul 2011). "Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis". PLOS Genetics. 7 (7): e1002091. doi:10.1371/journal.pgen.1002091. PMC 3131285. PMID 21750679.
9. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, et al. (Feb 2009). "Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways". Nature Genetics. 41 (2): 199–204. doi:10.1038/ng.311. PMC 2745122. PMID 19169254.
10. Bowes J, Orozco G, Flynn E, Ho P, Brier R, Marzo-Ortega H, et al. (Sep 2011). "Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis". Annals of the Rheumatic Diseases. 70 (9): 1641–4. doi:10.1136/ard.2011.150102. PMC 3147229. PMID 21623003.
11. Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, et al. (Nov 2009). "A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus". Nature Genetics. 41 (11): 1228–33. doi:10.1038/ng.468. PMC 2925843. PMID 19838195.
12. Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, et al. (Nov 2009). "Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus". Nature Genetics. 41 (11): 1234–7. doi:10.1038/ng.472. PMID 19838193. S2CID 205356205.
13. "TNIP1 (human)". www.phosphosite.org. Retrieved 2020-10-31.
14. Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, Haegeman G, Beyaert R (Jun 1999). "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN". The Journal of Cell Biology. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. PMC 2133159. PMID 10385526.
15. Charlaftis, Nikolaos; Suddason, Tesha; Wu, Xuefeng; Anwar, Saba; Karin, Michael; Gallagher, Ewen (2014-11-03). "The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines". The EMBO Journal. 33 (21): 2581–2596. doi:10.15252/embj.201488351. ISSN 1460-2075. PMC 4282369. PMID 25260751.
16. Zhang S, Fukushi M, Hashimoto S, Gao C, Huang L, Fukuyo Y, Nakajima T, Amagasa T, Enomoto S, Koike K, Miura O, Yamamoto N, Tsuchida N (Sep 2002). "A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling". Biochemical and Biophysical Research Communications. 297 (1): 17–23. doi:10.1016/S0006-291X(02)02086-7. PMID 12220502.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
• Loftus SK, Dixon J, Koprivnikar K, Dixon MJ, Wasmuth JJ (Jan 1996). "Transcriptional map of the Treacher Collins candidate gene region". Genome Research. 6 (1): 26–34. doi:10.1101/gr.6.1.26. PMID 8681136.
• Jäkel S, Görlich D (Aug 1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells". The EMBO Journal. 17 (15): 4491–502. doi:10.1093/emboj/17.15.4491. PMC 1170780. PMID 9687515.
• Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, Haegeman G, Beyaert R (Jun 1999). "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN". The Journal of Cell Biology. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. PMC 2133159. PMID 10385526.
• Zhang S, Fukushi M, Hashimoto S, Gao C, Huang L, Fukuyo Y, Nakajima T, Amagasa T, Enomoto S, Koike K, Miura O, Yamamoto N, Tsuchida N (Sep 2002). "A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling". Biochemical and Biophysical Research Communications. 297 (1): 17–23. doi:10.1016/S0006-291X(02)02086-7. PMID 12220502.
• Leonard D, Ajuh P, Lamond AI, Legerski RJ (Sep 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
• Gallagher J, Howlin J, McCarthy C, Murphy EP, Bresnihan B, FitzGerald O, Godson C, Brady HR, Martin F (Sep 2003). "Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays". FEBS Letters. 551 (1–3): 8–12. doi:10.1016/S0014-5793(03)00823-8. PMID 12965196. S2CID 2796577.
• Favre M, Butticaz C, Stevenson B, Jongeneel CV, Telenti A (Oct 2003). "High frequency of alternative splicing of human genes participating in the HIV-1 life cycle: a model using TSG101, betaTrCP, PPIA, INI1, NAF1, and PML". Journal of Acquired Immune Deficiency Syndromes. 34 (2): 127–33. doi:10.1097/00126334-200310010-00002. PMID 14526201.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Hoareau-Aveilla C, Bonoli M, Caizergues-Ferrer M, Henry Y (May 2006). "hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase". RNA. 12 (5): 832–40. doi:10.1261/rna.2344106. PMC 1440901. PMID 16601202.

External links

• TNIP1 human gene location in the UCSC Genome Browser.
• TNIP1 human gene details in the UCSC Genome Browser.