TMEM49

Transmembrane protein 49 is a protein that in humans is encoded by the TMEM49 gene.[5][6][7]

VMP1
Identifiers
Aliases	VMP1, EPG3, TANGO5, TMEM49, vacuole membrane protein 1
External IDs	OMIM: 611753 MGI: 1923159 HomoloGene: 23686 GeneCards: VMP1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.1 Start 59,707,192 bp[1] End 59,842,255 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 86,583,865 bp[2] End 86,683,836 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • vacuolar membrane • integral component of membrane • vacuole • cell membrane • autophagosome membrane • nucleolus • endoplasmic reticulum • membrane • pre-autophagosomal structure • endoplasmic reticulum-Golgi intermediate compartment membrane Biological process • autophagy • cell adhesion • Golgi organization • embryo implantation • endoplasmic reticulum organization • exocytosis • cell junction assembly • cell-cell adhesion • autophagosome assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81671	75909
Ensembl	ENSG00000062716	ENSMUSG00000018171
UniProt	Q96GC9	Q99KU0
RefSeq (mRNA)	NM_001329394 NM_001329395 NM_001329396 NM_001329397 NM_001329398 NM_001329399 NM_001329400 NM_001329401 NM_001329402 NM_030938	NM_029478 NM_001356531 NM_001379040 NM_001379041
RefSeq (protein)	NP_001316323 NP_001316324 NP_001316325 NP_001316326 NP_001316327 NP_001316328 NP_001316329 NP_001316330 NP_001316331 NP_112200	NP_083754 NP_001343460 NP_001365969 NP_001365970
Location (UCSC)	Chr 17: 59.71 – 59.84 Mb	Chr 11: 86.58 – 86.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000062716 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018171 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. Dusetti NJ, Jiang Y, Vaccaro MI, Tomasini R, Azizi Samir A, Calvo EL, Ropolo A, Fiedler F, Mallo GV, Dagorn JC, Iovanna JL (Jan 2002). "Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation". Biochem Biophys Res Commun. 290 (2): 641–9. doi:10.1006/bbrc.2001.6244. PMID 11785947.
7. "Entrez Gene: TMEM49 transmembrane protein 49".

Further reading

• Ropolo A, Grasso D, Pardo R, et al. (2008). "The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells". J. Biol. Chem. 282 (51): 37124–33. doi:10.1074/jbc.M706956200. PMID 17940279.
• Sauermann M, Sahin O, Sültmann H, et al. (2008). "Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells". Oncogene. 27 (9): 1320–6. doi:10.1038/sj.onc.1210743. PMID 17724469.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Starkuviene V, Liebel U, Simpson JC, et al. (2004). "High-content screening microscopy identifies novel proteins with a putative role in secretory membrane traffic". Genome Res. 14 (10A): 1948–56. doi:10.1101/gr.2658304. PMC 524419. PMID 15466293.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.