TFB2M

Dimethyladenosine transferase 2; transcription factor B2, mitochondrial is an enzyme that in humans is encoded by the TFB2M gene.[5]

TFB2M
Identifiers
Aliases	TFB2M, Hkp1, mtTFB2, transcription factor B2, mitochondrial
External IDs	OMIM: 607055 MGI: 107937 HomoloGene: 7362 GeneCards: TFB2M
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q44 Start 246,540,561 bp[1] End 246,566,261 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H4|1 83.56 cM Start 179,528,055 bp[2] End 179,546,267 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • transferase activity • GO:0001104 transcription coregulator activity • rRNA methyltransferase activity • rRNA (adenine-N6,N6-)-dimethyltransferase activity • RNA binding Cellular component • cell junction • mitochondrial nucleoid • mitochondrial matrix • mitochondrion Biological process • positive regulation of transcription, DNA-templated • rRNA processing • methylation • mitochondrion organization • regulation of transcription, DNA-templated • rRNA methylation • transcription, DNA-templated • transcription from mitochondrial promoter • transcription initiation from mitochondrial promoter • rRNA modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64216	15278
Ensembl	ENSG00000162851	ENSMUSG00000026492
UniProt	Q9H5Q4	Q3TL26
RefSeq (mRNA)	NM_022366	NM_008249 NM_001331054 NM_001331055
RefSeq (protein)	NP_071761	NP_001317983 NP_001317984 NP_032275
Location (UCSC)	Chr 1: 246.54 – 246.57 Mb	Chr 1: 179.53 – 179.55 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This protein is a transcription initiation factor for the mitochondrial RNA polymerase, POLRMT. Its paralog TFB1M can perform a similar function, but only in vitro.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000162851 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026492 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TFB2M transcription factor B2, mitochondrial".
6. Hillen, HS; Morozov, YI; Sarfallah, A; Temiakov, D; Cramer, P (16 November 2017). "Structural Basis of Mitochondrial Transcription Initiation". Cell. 171 (5): 1072–1081.e10. doi:10.1016/j.cell.2017.10.036. PMC 6590061. PMID 29149603.

Further reading

• Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94. doi:10.1038/ng909. PMID 12068295. S2CID 11164308.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rantanen A, Gaspari M, Falkenberg M, et al. (2003). "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2". Mamm. Genome. 14 (1): 1–6. doi:10.1007/s00335-002-2218-z. PMID 12532263. S2CID 25379746.
• McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Mol. Cell. Biol. 23 (16): 5816–24. doi:10.1128/MCB.23.16.5816-5824.2003. PMC 166325. PMID 12897151.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gaspari M, Falkenberg M, Larsson NG, Gustafsson CM (2005). "The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells". EMBO J. 23 (23): 4606–14. doi:10.1038/sj.emboj.7600465. PMC 533051. PMID 15526033.
• Gleyzer N, Vercauteren K, Scarpulla RC (2005). "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators". Mol. Cell. Biol. 25 (4): 1354–66. doi:10.1128/MCB.25.4.1354-1366.2005. PMC 548005. PMID 15684387.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Cotney J, Shadel GS (2007). "Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2". J. Mol. Evol. 63 (5): 707–17. doi:10.1007/s00239-006-0075-1. PMID 17031457. S2CID 7673903.
• Cotney J, Wang Z, Shadel GS (2007). "Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression". Nucleic Acids Res. 35 (12): 4042–54. doi:10.1093/nar/gkm424. PMC 1919481. PMID 17557812.