Susan Daniel

Susan Daniel is an American chemical engineer who is a Professor of Chemical and Biomolecular Engineering at Cornell University. Her research considers membrane biophysics and bioelectronic devices. During the COVID-19 pandemic Daniel used bioelectronic devices to develop coronavirus disease drugs.

Susan Daniel
Born
Philadelphia
Alma materLehigh University
Scientific career
InstitutionsCornell University
Texas A&M University
ThesisThe effect of vibration on liquid drop motion (2005)
InfluencesPierre-Gilles de Gennes
WebsiteDaniel Team

Early life and education

Daniel was born in suburban Philadelphia.[1] Her father was an immigrant from Germany, who relocated to Pennsylvania on leaving Europe.[1] Daniel was the first member of her family to attend college.[1] During high school she became inspired by chemistry.[1] She was an undergraduate student in chemical engineering at Lehigh University.[2] She wondered whether she might be interested in research, and visited the office of Manoj Chaudhury. He asked her to study the movement of liquid droplets on various surfaces with different surface tension. Remarkably, her first journey into research ended up published in Science, before she had even earned her master's degree. She remained at Lehigh University for her doctoral research, continuing to study the motion of liquid droplets on surfaces with different wettabilities.[1] As part of her droplet research, she developed technologies to manipulate fluids in miniature devices.[3] The devices she developed allowed the precise mixing of droplets as well as thermosensitive reactions.[3] Her research attracted considerable attention, and she started working with Pierre-Gilles de Gennes on how to create ratchet motion with the droplets.[3]

Research and career

After completing her doctorate Daniel joined the laboratory of Paul Cremer at Texas A&M University. Here she shifted focus, concentrating on biological interfaces and the development of cell membranes.[3] Specifically, Daniel worked on solid-supported lipid bilayers. She showed that an artificial glycocalyx-like nanostructure could serve as a size-selective filter for protein binding.[3] This achievement inspired Daniel to use the solid-supported lipid bilayers to separate membrane-bound species via electrophoresis.[3]

In 2007 Daniel joined Cornell University in the Smith School of Chemical and Biomolecular Engineering, where she leads two distinct research programmes, one focused on biological function and the other on surface science. She is interested in the role of membrane lipids in biological interactions, with a focus on how viruses interact with cell membranes. Her motivation to study virus – membrane interactions lies in the potential to hijack the virus and use it to perform specific tasks.[1]

She has identified the speed at which viral genomes are transferred out of viruses and into the cell membranes. Cell membranes contain a variety of proteins and biomolecules, which are held within a matrix of lipid phases. Daniel believes that the interactions of these lipid phases control the regulation of the function of the cell membrane.[1] Alongside her biology-focussed work, Daniel investigates the motion and coalescence of droplets.[1][3]

Daniel pioneered the development of biomembrane platforms that permit the recreation of cellular processes on a chip.[4] During the COVID-19 pandemic, Daniel worked with Róisín Owens, a biochemist she met whilst a visiting scholar at the École nationale supérieure des mines de Saint-Étienne, on devices that allowed the rapid testing of potential coronavirus drugs.[5] Daniel used membrane fusion to identify a specific targets for anti-viral drugs.[6] To continue her studies of coronaviruses, she was awarded seed-funding from the Office of the Vice Provost for Research (OVPR).[7][8]

Academic service

Daniel is involved with various initiatives to promote women in science. On arriving at Cornell University she became interested in the women's engineering group, and is a member of Women in Science and Engineering (WISE) at Cornell.[1] She was appointed Director of Graduate Studies at Cornell University in 2016, and under her leadership she recruited the most diverse class in the history of the school of Chemical and Biomolecular Engineering.[4]

Awards and honours

Selected publications
  • Daniel, S. (2001-01-26). "Fast Drop Movements Resulting from the Phase Change on a Gradient Surface". Science. 291 (5504): 633–636. Bibcode:2001Sci...291..633D. doi:10.1126/science.291.5504.633. ISSN 0036-8075. PMID 11158672.
  • Daniel, Susan; Chaudhury, Manoj K. (2002-04-01). "Rectified Motion of Liquid Drops on Gradient Surfaces Induced by Vibration". Langmuir. 18 (9): 3404–3407. doi:10.1021/la025505c. ISSN 0743-7463.
  • Daniel, Susan; Chaudhury, Manoj K.; de Gennes, P.-G. (2005-04-01). "Vibration-Actuated Drop Motion on Surfaces for Batch Microfluidic Processes". Langmuir. 21 (9): 4240–4248. doi:10.1021/la046886s. ISSN 0743-7463. PMID 15836001.

References
  1. "Susan Daniel | Cornell Engineering". www.engineering.cornell.edu. Retrieved 2020-09-27.
  2. "Susan Daniel | Chemistry & Chemical Biology Cornell Arts & Sciences". chemistry.cornell.edu. Retrieved 2020-09-27.
  3. "Professor Susan Daniel". Daniel Research Team. 2019-05-03. Retrieved 2020-09-27.
  4. "Susan Daniel | Smith School of Chemical and Biomolecular Engineering". www.cheme.cornell.edu. Retrieved 2020-09-27.
  5. "Cell 'membrane on a chip' could speed up screening of drug candidates for COVID-19". University of Cambridge. 2020-07-06. Retrieved 2020-09-27.
  6. "Seeking COVID cures: Scientists find promising first step in antiviral treatment | Smith School of Chemical and Biomolecular Engineering". www.cheme.cornell.edu. Retrieved 2020-09-28.
  7. "A Boost for New COVID-19 Research". Cornell Research. 2020-05-07. Retrieved 2020-09-28.
  8. "Pandemic injects new urgency into coronavirus collaborations". Cornell Chronicle. Retrieved 2020-09-28.
  9. "Two women faculty receive inaugural Schwartz awards". Cornell Chronicle. Retrieved 2020-09-27.
  10. "Seminar Series – Susan Daniel, Ph.D. – Department of Chemical Engineering". Retrieved 2020-09-27.
  11. "2022 Bioanalytical Sensors Conference GRC". www.grc.org. Retrieved 2020-09-27.
  12. "Susan Daniel received the Senior Faculty Champion Award | Smith School of Chemical and Biomolecular Engineering". www.cheme.cornell.edu. Retrieved 2020-09-28.
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