Serrate RNA effector molecule homolog

Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene.[5]

SRRT
Identifiers
Aliases	SRRT, ARS2, ASR2, serrate, serrate, RNA effector molecule
External IDs	OMIM: 614469 MGI: 1933527 HomoloGene: 9298 GeneCards: SRRT
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 100,875,103 bp[1] End 100,888,664 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 137,295,704 bp[2] End 137,307,674 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • nucleic acid binding • RNA binding Cellular component • cytoplasm • cell nucleus • nucleoplasm • macromolecular complex Biological process • positive regulation of neurogenesis • gene silencing by RNA • cellular proliferation • regulation of transcription, DNA-templated • response to arsenic-containing substance • transcription, DNA-templated • neuronal stem cell population maintenance • primary miRNA processing • mRNA splicing, via spliceosome • snRNA transcription from RNA polymerase II promoter • mRNA processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51593	83701
Ensembl	ENSG00000087087	ENSMUSG00000037364
UniProt	Q9BXP5	Q99MR6
RefSeq (mRNA)	NM_001128852 NM_001128853 NM_001128854 NM_015908 NM_182800	NM_001109909 NM_001109910 NM_031405 NM_001359602
RefSeq (protein)	NP_001122324 NP_001122325 NP_001122326 NP_056992	NP_001103379 NP_001103380 NP_113582 NP_001346531
Location (UCSC)	Chr 7: 100.88 – 100.89 Mb	Chr 5: 137.3 – 137.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The SRRT gene product plays a role in RNA-mediated gene silencing (RNAi) by miRNAs. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewal, by directly binding the SOX2 promoter and positively regulating its transcription.

It does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Diseases associated with SRRT include spondylocostal dysostosis.

References

1. GRCh38: Ensembl release 89: ENSG00000087087 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037364 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ARS2 ARS2 protein".

Further reading

• Rossman TG, Wang Z (1999). "Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis". Carcinogenesis. 20 (2): 311–6. doi:10.1093/carcin/20.2.311. PMID 10069470.
• Wilson MD, Riemer C, Martindale DW, et al. (2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5". Nucleic Acids Res. 29 (6): 1352–65. doi:10.1093/nar/29.6.1352. PMC 29746. PMID 11239002.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Di Y, Li J, Zhang Y, et al. (2004). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins". J. Biochem. 133 (6): 713–8. doi:10.1093/jb/mvg091. PMID 12869526.
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.