Secretory component

The secretory component is a component of immunoglobulin A (IgA). Secretory component is a proteolytic cleavage product of the polymeric immunoglobulin receptor which remains associated with dimeric IgA in sero-mucus secretions.[1] Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, are free to diffuse throughout the lumen.[2]

Schematic of immunoglobulin A dimer showing H-chain (blue), L-chain (red), J-chain (magenta) and secretory component (yellow).

Secretory components wrap around two IgA units joined by a J chain protein fragment, resulting in a >--< configuration, with each of the two antigen binding regions of the two constituent y-shaped antibodies exposed. One identified function of secretory components is to protect IgA antibodies from degradation by the gastric acids and enzymes of the digestive system. This property is especially important in the transfer of immune system components during breastfeeding.[3]

References
  1. Roitt, Ivan; Delves, Peter (2001). Essential Immunology (10th ed.). Blackwell Science. pp. 483. ISBN 0-632-05902-8.
  2. CS Kaetzel; JK Robinson; KR Chintalacharuvu; JP Vaerman & ME Lamm (1991). "The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA". Proc Natl Acad Sci USA. 88 (19): 8796–8800. doi:10.1073/pnas.88.19.8796. PMC 52597. PMID 1924341.
  3. Newman, Jack (December 1995). "How Breast Milk Protects Newborns". Scientific American: 76–80.
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