Samir Mitragotri

Samir Mitragotri (born 28 May 1971 in Solapur, India) is an Indian American professor at Harvard University, an inventor, an entrepreneur, and a researcher in the fields of drug delivery and biomaterials.[1] He is currently the Hiller Professor of Bioengineering and Hansjorg Wyss Professor of Biologically Inspired Engineering at Harvard John A. Paulson School of Engineering and Applied Sciences and the Wyss Institute for Biologically Inspired Engineering.[2] Prior to 2017, he was the Duncan and Suzanne Mellichamp Chair Professor at University of California, Santa Barbara.[3] [4]

Samir Mitragotri
Born (1971-05-28) 28 May 1971
Solapur, India
Alma materInstitute of Chemical Technology B.S., 1992
Massachusetts Institute of Technology M.S. and PhD, 1996
Known forDrug Delivery, Biomaterials
AwardsNational Academy of Engineering
National Academy of Medicine
Scientific career
FieldsChemical Engineering, Biomedical Engineering
InstitutionsHarvard University
Harvard John A. Paulson School of Engineering and Applied Sciences
Wyss Institute for Biologically Inspired Engineering
Doctoral advisorRobert S. Langer, Daniel Blankschtein

Mitragotri is widely recognized for his contributions to the field of drug delivery. He is considered a pioneer of many novel drug delivery technologies, especially in the fields of transdermal, oral and targeted systems. He invented techniques to deliver drugs transdermally using low-frequency ultrasound,[5] pulsed microjet injector,[6] high throughput skin experimentation,[7] skin penetrating peptides[8] and ionic liquids.[9] He also invented intestinal patches and ionic liquids for oral delivery of proteins.[10] Mitragotri also pioneered nanoparticle-enabled cell therapies which use drug-loaded nanoparticles that hitch a ride on red blood cells, monocytes and other circulatory cells for tissue-specific delivery.[11] Mitragotri’s technologies are used to develop next generation therapies against diabetes, cancer, psoriasis, hemorrhage, trauma and infections.

Mitragotri has published over 300 research publications, has given over 500 presentations worldwide, and is an inventor on over 180 patents/applications. His publications are cited with an h-index of 102.[12] Mitragotri is a member of U.S. National Academy of Engineering, National Academy of Medicine, and National Academy of Inventors. He is a co-founder of several companies that are developing products based on his inventions. He received his PhD in Chemical Engineering at MIT and BS in Chemical Engineering from the Institute of Chemical Technology. Mitragotri serves on the editorial boards of several journals and currently serves as Editor-in-Chief of Bioengineering and Translational Medicine.

Awards and honors

Mitragotri's national and international awards include:

Journal Associations
  • Editor-in-Chief, Bioengineering and Translational Medicine[29]
  • Associate Editor, Journal of Controlled Release[30]
  • Editorial Board, European Journal of Pharmaceutical Sciences[31]

Biotech Companies

Samir Mitragotri has co-founded several companies:

  • Sontra Medical, Inc. (acquired by Echo Therapeutics) [32]
  • fqubed, Inc. (acquired by Nuvo Research)
  • Stratagent LifeSciences (acquired by Corium International)
  • Seventh Sense Biosystems[33]
  • Dx Biosciences
  • Entrega[34]
  • Liquedon, LLC
  • CAGE Bio Inc.
  • Fount Biosciences
  • i2O Therapeutics

References
  1. "Mitragotri Laboratory". Drug Delivery. The President and Fellows of Harvard College. Retrieved 22 April 2018.
  2. "Renowned bioengineer to join Harvard faculty". Harvard John A. Paulson School of Engineering and Applied Sciences. President and Fellows of Harvard College. Retrieved 24 January 2017.
  3. "Endowed Chairs". UCSB Institutional Advancement, Office of Development. The Regents of the University of California. Retrieved 14 October 2014.
  4. People. UCSB Center for BioEngineering, The Regents of the University of California http://bioengineering.ucsb.edu/people. Retrieved 14 October 2014. Missing or empty |title= (help)
  5. Mitragotri, S.; Blankschtein, D.; Langer, R. (11 August 1995). "Ultrasound-mediated transdermal protein delivery". Science. 269 (5225): 850–853. Bibcode:1995Sci...269..850M. doi:10.1126/science.7638603. PMID 7638603.
  6. Arora, A.; Hakim, I.; Baxter, J.; Rathnasingham, R.; Srinivasan, R.; Fletcher, D. A.; Mitragotri, S. (6 March 2007). "Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets". Proceedings of the National Academy of Sciences. 104 (11): 4255–4260. Bibcode:2007PNAS..104.4255A. doi:10.1073/pnas.0700182104. PMC 1838589. PMID 17360511.
  7. Karande, Pankaj; Jain, Amit; Mitragotri, Samir (4 January 2004). "Discovery of transdermal penetration enhancers by high-throughput screening". Nature Biotechnology. 22 (2): 192–197. doi:10.1038/nbt928. PMID 14704682.
  8. Hsu, T.; Mitragotri, S. (8 September 2011). "Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer". Proceedings of the National Academy of Sciences. 108 (38): 15816–15821. Bibcode:2011PNAS..10815816H. doi:10.1073/pnas.1016152108. PMC 3179050. PMID 21903933.
  9. Zakrewsky, Michael; Lovejoy, Katherine S.; Kern, Theresa L.; Miller, Tarryn E.; Le, Vivian; Nagy, Amber; Goumas, Andrew M.; Iyer, Rashi S.; Del Sesto, Rico E.; Koppisch, Andrew T.; Fox, David T.; Mitragotri, Samir (16 September 2014). "Ionic liquids as a class of materials for transdermal delivery and pathogen neutralization". Proceedings of the National Academy of Sciences. 111 (37): 13313–13318. Bibcode:2014PNAS..11113313Z. doi:10.1073/pnas.1403995111. PMC 4169946. PMID 25157174.
  10. Banerjee, Amrita; Ibsen, Kelly; Brown, Tyler; Chen, Renwei; Agatemor, Christian; Mitragotri, Samir (25 June 2018). "Ionic liquids for oral insulin delivery". Proceedings of the National Academy of Sciences. 115 (28): 7296–7301. doi:10.1073/pnas.1722338115. ISSN 0027-8424. PMC 6048483. PMID 29941553.
  11. Anselmo, Aaron C.; Gupta, Vivek; Zern, Blaine J.; Pan, Daniel; Zakrewsky, Michael; Muzykantov, Vladimir; Mitragotri, Samir (23 December 2013). "Delivering Nanoparticles to Lungs while Avoiding Liver and Spleen through Adsorption on Red Blood Cells". ACS Nano. 7 (12): 11129–11137. doi:10.1021/nn404853z. PMC 4128963. PMID 24182189.
  12. "Samir Mitragotri". Google Scholar. Retrieved 14 May 2020.
  13. "2020 Awards Announced | Controlled Release Society (CRS)". www.controlledreleasesociety.org. Retrieved 15 November 2020.
  14. "Plenary Session I: Clemson Awards". Society for Biomaterials. Society for Biomaterials. Retrieved 27 February 2017.
  15. "National Academy of Medicine Elects 79 New Members". National Academy of Medicine. National Academy of Sciences. Retrieved 26 October 2016.
  16. "BMES members elected to 2015 National Academy of Engineers class". BMES. Biomedical Engineering Society. Retrieved 4 January 2016.
  17. Baumer, Katie. "AAPS Announces 2015 Fellows". AAPS. American Association of Pharmaceutical Scientists (AAPS). Retrieved 4 January 2016.
  18. "College of Fellows". Controlled Release Society. Controlled Release Society. Retrieved 1 July 2015.
  19. "Professional Progress in Chemical Engineering". AIChE: The Global Home of Chemical Engineers. American Institute of Chemical Engineers. Retrieved 1 July 2015.
  20. Atkins, Randy. "National Academy of Engineering Elects 67 Members and 12 Foreign Members". National Academy of Engineering. Retrieved 7 February 2015.
  21. "Current NAI Fellows". National Academy of Inventors. The National Academy of Inventors. Retrieved 14 October 2014.
  22. Fernandez, Sonia. "Two UCSB Engineering Professors Named to National Academy of Inventors". The UC Santa Barbara Current: Science & Technology. The Regents of the University of California. Retrieved 17 December 2013.
  23. "AAAS Members Elected as Fellows". AAAS. American Association for the Advancement of Science. Retrieved 30 November 2012.
  24. "Eight Distinguished UCSB Faculty Members Named AAAS Fellows". UCSB Institutional Advancement: Public Affairs & Communications. The Regents of the University of California. Retrieved 29 November 2012.
  25. "Fellow Directory". AIMBE. American Institute for Medical and Biological Engineering. Retrieved 30 September 2014.
  26. "CRS Young Investigator Award Recipients". CRS: Controlled Release Society. Controlled Release Society. Retrieved 14 October 2014.
  27. "Allan P. Colburn Award for Excellence in Publications by a Young Member of the Institute". AIChE: The Global Home of Chemical Engineers. American Institute of Chemical Engineers. Retrieved 14 October 2014.
  28. "Samir Mitragotri, 28". MIT Technology Review. MIT Technology Review.
  29. "Bioengineering & Translational Medicine". AIChE. American Institute of Chemical Engineers. Retrieved 4 January 2016.
  30. "Editorial Board, Journal of Controlled Release". Elsevier. Elsevier B.V. Retrieved 14 October 2014.
  31. "European Journal of Pharmaceutical Sciences Editorial Board". Elsevier. Elsevier B.V. Retrieved 14 October 2014.
  32. "Echo Therapeutics: Needle-free monitoring and drug delivery". Echo Therapeutics. Retrieved 14 October 2014.
  33. "Scientific Advisors". Seventh Sense Biosystems. Seventh Sense Biosystems, Inc. Archived from the original on 24 September 2014. Retrieved 14 October 2014.
  34. "Team". entrega. Entrega Bio. Retrieved 14 October 2014.
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