SUV420H1

Histone-lysine N-methyltransferase SUV420H1 is an enzyme that in humans is encoded by the SUV420H1 gene.[5][6][7] The enzyme along with WHSC1 is responsible for dimethylation of lysine 20 on histone 4 in mouse and humans.[8][9]

KMT5B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3S8P
Identifiers
Aliases	KMT5B, CGI85, CGI-85, SUV420H1, lysine methyltransferase 5B, MRD51
External IDs	OMIM: 610881 MGI: 2444557 HomoloGene: 32351 GeneCards: KMT5B
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 68,154,863 bp[1] End 68,213,828 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 3,767,421 bp[2] End 3,818,303 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • transferase activity • histone methyltransferase activity (H4-K20 specific) • histone-lysine N-methyltransferase activity • GO:0001948 protein binding Cellular component • condensed nuclear chromosome, centromeric region • chromosome • cell nucleus • nucleoplasm Biological process • histone H4-K20 trimethylation • muscle organ development • histone methylation • methylation • regulation of transcription, DNA-templated • transcription, DNA-templated • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51111	225888
Ensembl	ENSG00000110066	ENSMUSG00000045098
UniProt	Q4FZB7	Q3U8K7
RefSeq (mRNA)	NM_001300907 NM_001300908 NM_001300909 NM_016028 NM_017635 NM_001363566	NM_001167884 NM_001167885 NM_001167886 NM_001167887 NM_001167888 NM_001167889 NM_144871 NM_001379678 NM_001379679 NM_001379680
RefSeq (protein)	NP_001287836 NP_001287837 NP_001287838 NP_057112 NP_060105 NP_001350495 NP_001356353 NP_001356354 NP_001356355 NP_001356356 NP_001356357 NP_001356358 NP_001356359 NP_001356360 NP_001356361 NP_001356362	NP_001161356 NP_001161357 NP_001161358 NP_001161359 NP_001161360 NP_001161361 NP_659120 NP_001366607 NP_001366608 NP_001366609
Location (UCSC)	Chr 11: 68.15 – 68.21 Mb	Chr 19: 3.77 – 3.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript variants have been found for this gene.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000110066 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045098 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
6. Twells RC, Metzker ML, Brown SD, Cox R, Garey C, Hammond H, Hey PJ, Levy E, Nakagawa Y, Philips MS, Todd JA, Hess JF (Jun 2001). "The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13". Genomics. 72 (3): 231–42. doi:10.1006/geno.2000.6492. PMID 11401438.
7. "Entrez Gene: SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)".
8. Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T (2008). "A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse". Genes Dev. 22 (15): 2048–61. doi:10.1101/gad.476008. PMC 2492754. PMID 18676810.
9. Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, Bergsagel PL, Wang L, You Z, Lou Z (2011). "MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites". Nature. 470 (7332): 124–8. doi:10.1038/nature09658. PMC 3064261. PMID 21293379.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tryndyak VP, Kovalchuk O, Pogribny IP (2006). "Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins". Cancer Biol. Ther. 5 (1): 65–70. doi:10.4161/cbt.5.1.2288. PMID 16322686.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.