SUDS3

Sin3 histone deacetylase corepressor complex component SDS3 is an enzyme that in humans is encoded by the SUDS3 gene.[5][6]

SUDS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2N2H, 4ZQA
Identifiers
Aliases	SUDS3, SAP45, SDS3, SDS3 homolog, SIN3A corepressor complex component
External IDs	OMIM: 608250 MGI: 1919204 HomoloGene: 15906 GeneCards: SUDS3
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.23 Start 118,376,555 bp[1] End 118,418,033 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 117,091,680 bp[2] End 117,116,113 bp[2]
Gene ontology Molecular function • histone deacetylase binding • GO:0001948 protein binding • enzyme binding • histone deacetylase activity Cellular component • Sin3 complex • nucleoplasm • Sin3-type complex • cell nucleus • cytosol • nuclear body Biological process • regulation of transcription, DNA-templated • substantia nigra development • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of apoptotic process • negative regulation of transcription, DNA-templated • histone deacetylation • apoptotic process • covalent chromatin modification • protein deubiquitination • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64426	71954
Ensembl	ENSG00000111707	ENSMUSG00000066900
UniProt	Q9H7L9	Q8BR65
RefSeq (mRNA)	NM_022491	NM_001122666 NM_178622
RefSeq (protein)	NP_071936	NP_001116138 NP_848737
Location (UCSC)	Chr 12: 118.38 – 118.42 Mb	Chr 5: 117.09 – 117.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM][6]

Interactions

SUDS3 has been shown to interact with HDAC1,[5][7] Host cell factor C1,[8] SIN3B[5] and SIN3A.[5][7]

References

1. GRCh38: Ensembl release 89: ENSG00000111707 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066900 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (April 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology. 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966.
6. "Entrez Gene: SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)".
7. Fleischer TC, Yun UJ, Ayer DE (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
8. Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (April 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Fleischer TC, Yun UJ, Ayer DE (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
• Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (April 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.
• Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (December 2000). "Characterization of long cDNA clones from human adult spleen". DNA Research. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.