STRN4

Striatin-4 is a protein that in humans is encoded by the STRN4 gene.[5][6]

STRN4
Identifiers
Aliases	STRN4, ZIN, zinedin, PPP2R6C, striatin 4
External IDs	OMIM: 614767 MGI: 2142346 HomoloGene: 8378 GeneCards: STRN4
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 46,719,511 bp[1] End 46,746,994 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A2 Start 16,815,889 bp[2] End 16,840,931 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein phosphatase 2A binding • GO:0001948 protein binding • calmodulin binding • armadillo repeat domain binding • protein domain specific binding • GO:0032403 macromolecular complex binding Cellular component • cytoplasm • dendritic spine • protein phosphatase type 2A complex • cell projection • membrane • macromolecular complex • dendrite • FAR/SIN/STRIPAK complex Biological process • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29888	97387
Ensembl	ENSG00000090372	ENSMUSG00000030374
UniProt	Q9NRL3	P58404
RefSeq (mRNA)	NM_001039877 NM_013403	NM_001039878 NM_133789
RefSeq (protein)	NP_001034966 NP_037535	NP_001034967 NP_598550
Location (UCSC)	Chr 19: 46.72 – 46.75 Mb	Chr 7: 16.82 – 16.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

STRN4 has been shown to interact with STK24.[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000090372 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030374 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Castets F, Rakitina T, Gaillard S, Moqrich A, Mattei MG, Monneron A (Aug 2000). "Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain". J. Biol. Chem. 275 (26): 19970–7. doi:10.1074/jbc.M909782199. PMID 10748158.
6. "Entrez Gene: STRN4 striatin, calmodulin binding protein 4".
7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
8. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Gaillard S, Bartoli M, Castets F, Monneron A (2001). "Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1". FEBS Lett. 508 (1): 49–52. doi:10.1016/S0014-5793(01)03020-4. PMID 11707266. S2CID 7887096.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.