STAU1

Double-stranded RNA-binding protein Staufen homolog 1 is a protein that in humans is encoded by the STAU1 gene.[5][6][7]

STAU1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSTAU1, PPP1R150, STAU, staufen double-stranded RNA binding protein 1
External IDsOMIM: 601716 MGI: 1338864 HomoloGene: 3384 GeneCards: STAU1
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q13.13Start49,113,339 bp[1]
End49,188,367 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6780

20853

Ensembl

ENSG00000124214

ENSMUSG00000039536

UniProt

O95793

Q9Z108

RefSeq (mRNA)

NM_001109905
NM_001109906
NM_001291160
NM_011490

RefSeq (protein)

NP_001103375
NP_001103376
NP_001278089
NP_035620

Location (UCSC)Chr 20: 49.11 – 49.19 MbChr 2: 166.95 – 167 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule-binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.[7]

STAU1 is associated with stress granules.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000124214 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000039536 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. DesGroseillers L, Lemieux N (Feb 1997). "Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization". Genomics. 36 (3): 527–529. doi:10.1006/geno.1996.0499. PMID 8884277.
  6. Kim YK, Furic L, Desgroseillers L, Maquat LE (Jan 2005). "Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay". Cell. 120 (2): 195–208. doi:10.1016/j.cell.2004.11.050. PMID 15680326. S2CID 16786108.
  7. "Entrez Gene: STAU1 staufen, RNA binding protein, homolog 1 (Drosophila)".
  8. Thomas MG, Martinez Tosar LJ, Loschi M, Pasquini JM, Correale J, Kindler S, Boccaccio GL (January 2005). "Staufen recruitment into stress granules does not affect early mRNA transport in oligodendrocytes". Molecular Biology of the Cell. 16 (1): 405–420. doi:10.1091/mbc.E04-06-0516. PMC 539183. PMID 15525674.

Further reading

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