SRI (gene)

Sorcin is a protein that in humans is encoded by the SRI gene.[5][6]

SRI
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSRI, CP-22, CP22, SCN, V19, sorcin
External IDsOMIM: 182520 MGI: 98419 HomoloGene: 37736 GeneCards: SRI
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q21.12Start88,205,118 bp[1]
End88,226,993 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6717

109552

Ensembl

ENSG00000075142

ENSMUSG00000003161

UniProt

P30626

Q6P069

RefSeq (mRNA)

NM_001256891
NM_001256892
NM_003130
NM_198901

NM_001080974
NM_025618

RefSeq (protein)

NP_001243820
NP_001243821
NP_003121
NP_944490

NP_001074443
NP_079894

Location (UCSC)Chr 7: 88.21 – 88.23 MbChr 5: 8.05 – 8.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

SRI (gene) has been shown to interact with Ryanodine receptor 2,[7] ANXA7[8] and GCA.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000075142 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003161 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Van der Bliek AM, Baas F, Van der Velde-Koerts T, Biedler JL, Meyers MB, Ozols RF, Hamilton TC, Joenje H, Borst P (November 1988). "Genes amplified and overexpressed in human multidrug-resistant cell lines". Cancer Research. 48 (21): 5927–32. PMID 2901906.
  6. "Entrez Gene: SRI sorcin".
  7. Meyers MB, Pickel VM, Sheu SS, Sharma VK, Scotto KW, Fishman GI (November 1995). "Association of sorcin with the cardiac ryanodine receptor". The Journal of Biological Chemistry. 270 (44): 26411–8. doi:10.1074/jbc.270.44.26411. PMID 7592856.
  8. Brownawell AM, Creutz CE (August 1997). "Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)". The Journal of Biological Chemistry. 272 (35): 22182–90. doi:10.1074/jbc.272.35.22182. PMID 9268363.
  9. Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (June 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Letters. 545 (2–3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766. S2CID 42572647.

Further reading


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