SPRY4

Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.[5][6]

SPRY4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BUN
Identifiers
Aliases	SPRY4, HH17, sprouty RTK signaling antagonist 4
External IDs	OMIM: 607984 MGI: 1345144 HomoloGene: 8042 GeneCards: SPRY4
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 142,310,427 bp[1] End 142,326,455 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B3|18 20.5 cM Start 38,586,247 bp[2] End 38,601,415 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • ruffle membrane • cell membrane • cell projection • membrane • focal adhesion • cytoplasm • cytosol Biological process • multicellular organism development • negative regulation of ERK1 and ERK2 cascade • regulation of signal transduction • negative regulation of fibroblast growth factor receptor signaling pathway • negative regulation of MAP kinase activity • negative regulation of Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81848	24066
Ensembl	ENSG00000187678	ENSMUSG00000024427
UniProt	Q9C004	Q9WTP2
RefSeq (mRNA)	NM_001127496 NM_001293289 NM_001293290 NM_030964	NM_011898
RefSeq (protein)	NP_001120968 NP_001280218 NP_001280219 NP_112226	NP_036028
Location (UCSC)	Chr 5: 142.31 – 142.33 Mb	Chr 18: 38.59 – 38.6 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[6]

Interactions

SPRY4 has been shown to interact with TESK1.[7]

See also

• MAPK signaling pathway
• Ras subfamily

References

1. GRCh38: Ensembl release 89: ENSG00000187678 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024427 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Katoh Y, Katoh M (Mar 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine. 17 (3): 529–32. doi:10.3892/ijmm.17.3.529. PMID 16465403.
6. "Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)".
7. Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry / FEBS. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.

Further reading

• Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O'Donovan MC, Toncheva D (2008). "Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping". BMC Psychiatry. 8: 11. doi:10.1186/1471-244X-8-11. PMC 2268687. PMID 18298822.
• Cabrita MA, Jäggi F, Widjaja SP, Christofori G (Sep 2006). "A functional interaction between sprouty proteins and caveolin-1". The Journal of Biological Chemistry. 281 (39): 29201–12. doi:10.1074/jbc.M603921200. PMID 16877379.
• Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B (May 2006). "Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer". The Prostate. 66 (6): 613–24. doi:10.1002/pros.20353. PMID 16388505. S2CID 43803094.
• Ding W, Bellusci S, Shi W, Warburton D (Jul 2004). "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis". American Journal of Physiology. Lung Cellular and Molecular Physiology. 287 (1): L52-9. doi:10.1152/ajplung.00430.2003. PMID 14977631.
• Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A (May 2003). "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1". Nature Cell Biology. 5 (5): 427–32. doi:10.1038/ncb978. PMID 12717443. S2CID 33846459.
• Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry / FEBS. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein sprouty homolog 4 (SPRY4)