SPN1

Snurportin1 is a protein that in humans is encoded by the SNUPN gene.[5][6]

SNUPN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XK5, 2P8Q, 2Q5D, 2QNA, 3GB8, 3GJX, 3LWW, 3NBY, 3NBZ, 3NC0
Identifiers
Aliases	SNUPN, KPNBL, RNUT1, Snurportin1, snurportin 1
External IDs	OMIM: 607902 MGI: 1913319 HomoloGene: 4166 GeneCards: SNUPN
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.2 Start 75,598,083 bp[1] End 75,626,469 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 56,950,878 bp[2] End 56,983,206 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA cap binding • RNA binding • GO:0001948 protein binding • nuclear import signal receptor activity Cellular component • cytoplasm • cytosol • nuclear pore • cell nucleus • intracellular Biological process • snRNA import into nucleus • protein import into nucleus • spliceosomal snRNP assembly • nuclear import Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10073	66069
Ensembl	ENSG00000169371	ENSMUSG00000055334
UniProt	O95149	Q80W37
RefSeq (mRNA)	NM_005701 NM_001042581 NM_001042588	NM_178374
RefSeq (protein)	NP_001036046 NP_001036053 NP_005692	NP_848461
Location (UCSC)	Chr 15: 75.6 – 75.63 Mb	Chr 9: 56.95 – 56.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000169371 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055334 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Huber J, Cronshagen U, Kadokura M, Marshallsay C, Wada T, Sekine M, Luhrmann R (Sep 1998). "Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure". EMBO J. 17 (14): 4114–26. doi:10.1093/emboj/17.14.4114. PMC 1170744. PMID 9670026.
6. "Entrez Gene: SNUPN snurportin 1".

Further reading

• Paraskeva E, Izaurralde E, Bischoff FR, et al. (1999). "CRM1-mediated recycling of snurportin 1 to the cytoplasm". J. Cell Biol. 145 (2): 255–64. doi:10.1083/jcb.145.2.255. PMC 2133107. PMID 10209022.
• Narayanan U, Ospina JK, Frey MR, et al. (2003). "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta". Hum. Mol. Genet. 11 (15): 1785–95. doi:10.1093/hmg/11.15.1785. PMC 1630493. PMID 12095920.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strasser A, Dickmanns A, Lührmann R, Ficner R (2005). "Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1". EMBO J. 24 (13): 2235–43. doi:10.1038/sj.emboj.7600701. PMC 1173142. PMID 15920472.
• Ospina JK, Gonsalvez GB, Bednenko J, et al. (2006). "Cross-talk between snurportin1 subdomains". Mol. Biol. Cell. 16 (10): 4660–71. doi:10.1091/mbc.E05-04-0316. PMC 1237072. PMID 16030253.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.

External links

• SNUPN human gene location in the UCSC Genome Browser.
• SNUPN human gene details in the UCSC Genome Browser.