SLC8B1

Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 is a protein that in humans is encoded by the SLC8B1 gene.[5]

SLC8B1
Identifiers
Aliases	SLC8B1, NCKX6, NCLX, SLC24A6, solute carrier family 8 member B1
External IDs	OMIM: 609841 MGI: 2180781 HomoloGene: 41602 GeneCards: SLC8B1
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.13 Start 113,298,759 bp[1] End 113,359,493 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 120,511,168 bp[2] End 120,534,024 bp[2]
Gene ontology Molecular function • protein homodimerization activity • identical protein binding • antiporter activity • calcium:cation antiporter activity • calcium:sodium antiporter activity • calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential Cellular component • integral component of membrane • membrane • cell membrane • mitochondrial crista • mitochondrion • integral component of mitochondrial membrane • sarcolemma • mitochondrial inner membrane Biological process • sodium ion transmembrane transport • regulation of cytosolic calcium ion concentration • glucose homeostasis • response to stimulus • regulation of insulin secretion • sodium ion transport • ion transport • calcium ion transmembrane transport • regulation of cardiac muscle cell membrane potential • calcium ion transport • transmembrane transport • mitochondrial calcium ion transmembrane transport • mitochondrial calcium ion homeostasis • mitochondrial calcium release • regulation of lymphocyte chemotaxis • regulation of store-operated calcium entry Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80024	170756
Ensembl	ENSG00000089060	ENSMUSG00000032754
UniProt	Q6J4K2	Q925Q3
RefSeq (mRNA)	NM_024959 NM_001330466 NM_001358345	NM_001177594 NM_001177595 NM_133221
RefSeq (protein)	NP_001317395 NP_079235 NP_001345274	NP_001171065 NP_001171066 NP_573484
Location (UCSC)	Chr 12: 113.3 – 113.36 Mb	Chr 5: 120.51 – 120.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SLC24A6 belongs to a family of Potassium-dependent sodium-calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000089060 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032754 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1".
6. Cai X, Lytton J (February 2004). "Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6". The Journal of Biological Chemistry. 279 (7): 5867–76. doi:10.1074/jbc.M310908200. PMID 14625281.

Further reading

• Boyman L, Williams GS, Khananshvili D, Sekler I, Lederer WJ (June 2013). "NCLX: the mitochondrial sodium calcium exchanger". Journal of Molecular and Cellular Cardiology. 59: 205–13. doi:10.1016/j.yjmcc.2013.03.012. PMC 3951392. PMID 23538132.
• Palty R, Ohana E, Hershfinkel M, Volokita M, Elgazar V, Beharier O, Silverman WF, Argaman M, Sekler I (June 2004). "Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger". The Journal of Biological Chemistry. 279 (24): 25234–40. doi:10.1074/jbc.M401229200. PMID 15060069.
• Aslibekyan S, An P, Frazier-Wood AC, Kabagambe EK, Irvin MR, Straka RJ, Tiwari HK, Tsai MY, Hopkins PN, Borecki IB, Ordovas JM, Arnett DK (October 2013). "Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network". Nutrition, Metabolism, and Cardiovascular Diseases. 23 (10): 987–94. doi:10.1016/j.numecd.2012.07.010. PMC 3578131. PMID 23149075.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.