SHOC2

Leucine-rich repeat protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene.[5][6][7][8] Mutations that result in lipidation (specifically Myristoylation) of SHOC2 can cause Noonan syndrome.[9]

SHOC2
Identifiers
Aliases	SHOC2, SIAA0862, SOC2, SUR8, SHOC2 leucine-rich repeat scaffold protein, leucine rich repeat scaffold protein, SHOC2 leucine rich repeat scaffold protein
External IDs	OMIM: 602775 MGI: 1927197 HomoloGene: 7219 GeneCards: SHOC2
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.2 Start 110,919,547 bp[1] End 111,013,667 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D2 Start 53,944,306 bp[2] End 54,033,133 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein phosphatase 1 binding • protein phosphatase regulator activity • protein phosphatase binding • GO:0001948 protein binding • protein serine/threonine phosphatase activity Cellular component • protein phosphatase type 1 complex • nucleoplasm • cell nucleus • cytoplasm • cytosol • cell membrane • photoreceptor inner segment • photoreceptor outer segment membrane Biological process • fibroblast growth factor receptor signaling pathway • positive regulation of Ras protein signal transduction • Ras protein signal transduction • regulation of phosphoprotein phosphatase activity • protein dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8036	56392
Ensembl	ENSG00000108061	ENSMUSG00000024976
UniProt	Q9UQ13	O88520
RefSeq (mRNA)	NM_001269039 NM_007373 NM_001324336 NM_001324337	NM_001168505 NM_019658 NM_001355242
RefSeq (protein)	NP_001255968 NP_001311265 NP_001311266 NP_031399	NP_001161977 NP_062632 NP_001342171
Location (UCSC)	Chr 10: 110.92 – 111.01 Mb	Chr 19: 53.94 – 54.03 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SHOC2 has been shown to interact with C-Raf[7] and HRAS.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000108061 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024976 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Selfors LM, Schutzman JL, Borland CZ, Stern MJ (Jul 1998). "soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6903–8. doi:10.1073/pnas.95.12.6903. PMC 22679. PMID 9618511.
6. Sieburth DS, Sun Q, Han M (Aug 1998). "SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans". Cell. 94 (1): 119–30. doi:10.1016/S0092-8674(00)81227-1. PMID 9674433. S2CID 13102676.
7. Li W, Han M, Guan KL (May 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. 14 (8): 895–900. PMC 316541. PMID 10783161.
8. "Entrez Gene: SHOC2 soc-2 suppressor of clear homolog (C. elegans)".
9. Cordeddu V, Di Schiavi E, Pennacchio LA, Ma'ayan A, Sarkozy A, Fodale V, Cecchetti S, Cardinale A, Martin J, Schackwitz W, Lipzen A, Zampino G, Mazzanti L, Digilio MC, Martinelli S, Flex E, Lepri F, Bartholdi D, Kutsche K, Ferrero GB, Anichini C, Selicorni A, Rossi C, Tenconi R, Zenker M, Merlo D, Dallapiccola B, Iyengar R, Bazzicalupo P, Gelb BD, Tartaglia M (Sep 2009). "Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair". Nature Genetics. 41 (9): 1022–6. doi:10.1038/ng.425. PMC 2765465. PMID 19684605.

Further reading

• Dai P, Xiong WC, Mei L (2006). "Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex". J. Biol. Chem. 281 (2): 927–33. doi:10.1074/jbc.M507360200. PMID 16301319.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.