SGTA

Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene.[5][6][7] SGTA orthologs [8] have also been identified in several mammals for which complete genome data are available.

SGTA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VYI, 4CPG, 4GOD, 4GOE, 4GOF
Identifiers
Aliases	SGTA, SGT, alphaSGT, hSGT, small glutamine rich tetratricopeptide repeat containing alpha
External IDs	OMIM: 603419 MGI: 1098703 HomoloGene: 31122 GeneCards: SGTA
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,754,715 bp[1] End 2,783,282 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 81,044,075 bp[2] End 81,060,181 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • BAT3 complex binding • protein self-association • identical protein binding • GO:0032947 molecular adaptor activity Cellular component • cytosol • membrane • cell nucleus • cytoplasm • presynapse • extrinsic component of synaptic vesicle membrane • TRC complex Biological process • positive regulation of ER-associated ubiquitin-dependent protein catabolic process • GO:0022415 viral process • ubiquitin-dependent ERAD pathway • negative regulation of ER-associated ubiquitin-dependent protein catabolic process • negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process • tail-anchored membrane protein insertion into ER membrane • chaperone-mediated protein folding • posttranslational protein targeting to endoplasmic reticulum membrane • positive regulation of chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6449	52551
Ensembl	ENSG00000104969	ENSMUSG00000004937
UniProt	O43765	Q8BJU0
RefSeq (mRNA)	NM_003021	NM_024499 NM_001358549 NM_001358550
RefSeq (protein)	NP_003012	NP_078775 NP_001345478 NP_001345479
Location (UCSC)	Chr 19: 2.75 – 2.78 Mb	Chr 10: 81.04 – 81.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.[7]

Interactions

SGTA has been shown to interact with Growth hormone receptor.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000104969 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004937 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kordes E, Savelyeva L, Schwab M, Rommelaere J, Jauniaux JC, Cziepluch C (Aug 1998). "Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans". Genomics. 52 (1): 90–94. doi:10.1006/geno.1998.5385. PMID 9740675.
6. Schantl JA, Roza M, De Jong AP, Strous GJ (Aug 2003). "Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor". The Biochemical Journal. 373 (Pt 3): 855–863. doi:10.1042/BJ20021591. PMC 1223544. PMID 12735788.
7. "Entrez Gene: SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha".
8. "OrthoMaM phylogenetic marker: SGTA coding sequence".

Further reading

• Roberts JD, Thapaliya A, Martínez-Lumbreras S, Krysztofinska EM, Isaacson RL (Dec 2015). "Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha". Frontiers in Molecular Biosciences. 2: 71. doi:10.3389/fmolb.2015.00071. PMC 4683186. PMID 26734616.
• Heavner GA, Audhya T, Goldstein G (Feb 1990). "Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines". Regulatory Peptides. 27 (2): 257–262. doi:10.1016/0167-0115(90)90044-W. PMID 2158125. S2CID 12562672.Geraghty RJ, Talbot KJ, Callahan M, Harper W, Panganiban AT (1994). "Cell type-dependence for Vpu function". Journal of Medical Primatology. 23 (2–3): 146–150. doi:10.1111/j.1600-0684.1994.tb00115.x. PMID 7966229. S2CID 20674152.
• Cziepluch C, Kordes E, Poirey R, Grewenig A, Rommelaere J, Jauniaux JC (May 1998). "Identification of a novel cellular TPR-containing protein, SGT, that interacts with the nonstructural protein NS1 of parvovirus H-1". Journal of Virology. 72 (5): 4149–4156. doi:10.1128/JVI.72.5.4149-4156.1998. PMC 109644. PMID 9557704.
• Callahan MA, Handley MA, Lee YH, Talbot KJ, Harper JW, Panganiban AT (Jun 1998). "Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family". Journal of Virology. 72 (6): 5189–5197. doi:10.1128/JVI.72.6.5189-5197.1998. PMC 110095. PMID 9573291.
• Callahan MA, Handley MA, Lee YH, Talbot KJ, Harper JW, Panganiban AT (Oct 1998). "Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family". Journal of Virology. 72 (10): 8461. doi:10.1128/JVI.72.10.8460c-8460c.1998. PMC 110251. PMID 9766974.
• Liu FH, Wu SJ, Hu SM, Hsiao CD, Wang C (Nov 1999). "Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats". The Journal of Biological Chemistry. 274 (48): 34425–34432. doi:10.1074/jbc.274.48.34425. PMID 10567422.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Handley MA, Paddock S, Dall A, Panganiban AT (Dec 2001). "Association of Vpu-binding protein with microtubules and Vpu-dependent redistribution of HIV-1 Gag protein". Virology. 291 (2): 198–207. doi:10.1006/viro.2001.1166. PMID 11878889.
• Angeletti PC, Walker D, Panganiban AT (Jul 2002). "Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity". Cell Stress & Chaperones. 7 (3): 258–268. doi:10.1379/1466-1268(2002)007<0258:SGRPVP>2.0.CO;2. PMC 514826. PMID 12482202.
• Pai MT, Yang CS, Tzeng SR, Wang C, Cheng JW (Aug 2003). "1H, 15N and 13C resonance assignments of the tetratricopeptide repeat (TPR) domain of hSGT". Journal of Biomolecular NMR. 26 (4): 381–382. doi:10.1023/A:1024029117511. PMID 12815268. S2CID 19544209.
• Wang H, Zhang Q, Zhu D (Nov 2003). "hSGT interacts with the N-terminal region of myostatin". Biochemical and Biophysical Research Communications. 311 (4): 877–883. doi:10.1016/j.bbrc.2003.10.080. PMID 14623262.
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–167. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Winnefeld M, Rommelaere J, Cziepluch C (Feb 2004). "The human small glutamine-rich TPR-containing protein is required for progress through cell division". Experimental Cell Research. 293 (1): 43–57. doi:10.1016/j.yexcr.2003.09.028. PMID 14729056.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.