SFSWAP

Splicing factor, suppressor of white-apricot homolog is a protein in humans that is encoded by the SFSWAP gene.[5]

SFSWAP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E5Z, 2E60
Identifiers
Aliases	SFSWAP, SFRS8, SWAP, splicing factor SWAP homolog, splicing factor SWAP
External IDs	OMIM: 601945 MGI: 101760 HomoloGene: 134548 GeneCards: SFSWAP
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.33 Start 131,711,081 bp[1] End 131,799,737 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G1.3 Start 129,501,221 bp[2] End 129,571,384 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • RNA binding Cellular component • cell nucleus Biological process • mRNA processing • RNA processing • negative regulation of mRNA splicing, via spliceosome • regulation of transcription, DNA-templated • alternative mRNA splicing, via spliceosome • transcription, DNA-templated • RNA splicing • mRNA 5'-splice site recognition Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6433	231769
Ensembl	ENSG00000061936	ENSMUSG00000029439
UniProt	Q12872	Q3USH5
RefSeq (mRNA)	NM_001261411 NM_004592 NM_152235	NM_001035259 NM_172276 NM_001359952 NM_001378915 NM_001378916 NM_001378917
RefSeq (protein)	NP_001248340 NP_004583	NP_758480 NP_001346881 NP_001365844 NP_001365845 NP_001365846
Location (UCSC)	Chr 12: 131.71 – 131.8 Mb	Chr 5: 129.5 – 129.57 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000061936 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029439 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Splicing factor, suppressor of white-apricot homolog (Drosophila)". Retrieved 2013-05-08.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Splicing factor, suppressor of white-apricot homolog (SFSWAP)