SERINC3

Serine incorporator 3 is a protein that in humans is encoded by the SERINC3 gene.[5][6] It has been demonstrated that SERINC3 acts as a retrovirus restriction factor. [7][8][9]

SERINC3
Identifiers
AliasesSERINC3, AIGP1, DIFF33, SBBI99, TDE, TDE1, TMS-1, serine incorporator 3
External IDsOMIM: 607165 MGI: 1349457 HomoloGene: 38230 GeneCards: SERINC3
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q13.12Start44,496,221 bp[1]
End44,522,085 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10955

26943

Ensembl

ENSG00000132824

ENSMUSG00000017707

UniProt

Q13530

Q9QZI9

RefSeq (mRNA)

NM_198941
NM_006811

NM_012032

RefSeq (protein)

NP_006802
NP_945179

NP_036162

Location (UCSC)Chr 20: 44.5 – 44.52 MbChr 2: 163.62 – 163.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of SERINC3 function. A conditional knockout mouse line called Serinc3tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[10] Male and female animals underwent a standardized phenotypic screen[11] to determine the effects of deletion.[12][13][14][15] Additional screens performed: - In-depth immunological phenotyping[16]

References

  1. GRCh38: Ensembl release 89: ENSG00000132824 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000017707 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bossolasco M, Lebel M, Lemieux N, Mes-Masson AM (November 1999). "The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue". Molecular Carcinogenesis. 26 (3): 189–200. doi:10.1002/(SICI)1098-2744(199911)26:3<189::AID-MC8>3.0.CO;2-T. PMID 10559794.
  6. "Entrez Gene: SERINC3 serine incorporator 3".
  7. Rosa A, Chande A, Ziglio S, De Sanctis V, Bertorelli R, Goh SL, et al. (October 2015). "HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation". Nature. 526 (7572): 212–7. doi:10.1038/nature15399. PMC 4861059. PMID 26416734.
  8. Chande A, Cuccurullo EC, Rosa A, Ziglio S, Carpenter S, Pizzato M (November 2016). "S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3". Proceedings of the National Academy of Sciences of the United States of America. 113 (46): 13197–13202. doi:10.1073/pnas.1612044113. PMC 5135340. PMID 27803322.
  9. Ramdas P, Bhardwaj V, Singh A, Vijay N, Chande A (2020-02-24). "Coevolution of retroviruses with SERINCs following whole-genome duplication divergence". bioRxiv. doi:10.1101/2020.02.24.962506.
  10. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  11. "International Mouse Phenotyping Consortium".
  12. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, et al. (June 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  13. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  14. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  15. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, et al. (July 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  16. "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

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