SEPP1

Selenoprotein P is a protein that in humans is encoded by the SEPP1 gene.[5][6]

SELENOP
Identifiers
Aliases	SELENOP, SELP, SeP, SEPP, SEPP1, selenoprotein P, plasma, 1, selenoprotein P
External IDs	OMIM: 601484 MGI: 894288 HomoloGene: 3945 GeneCards: SELENOP
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p12 Start 42,799,880 bp[1] End 42,887,392 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 A1|15 1.84 cM Start 3,268,547 bp[2] End 3,280,508 bp[2]
Gene ontology Molecular function • selenium binding Cellular component • extracellular exosome • platelet dense granule lumen • extracellular region • extracellular Biological process • brain development • post-embryonic development • sexual reproduction • response to oxidative stress • locomotory behavior • selenium compound metabolic process • platelet degranulation • growth • response to selenium ion • regulation of growth Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6414	20363
Ensembl	ENSG00000250722	ENSMUSG00000064373
UniProt	P49908	P70274
RefSeq (mRNA)	NM_005410 NM_001085486 NM_001093726	NM_001042613 NM_001042614 NM_009155
RefSeq (protein)	NP_001078955 NP_001087195 NP_005401	NP_001036078 NP_001036079 NP_033181
Location (UCSC)	Chr 5: 42.8 – 42.89 Mb	Chr 15: 3.27 – 3.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues (human, rat, mouse - see Burk and Hill 2009) per polypeptide, one of which located at the C-termial side of protein and others at the N-terminal side. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000250722 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000064373 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hill KE, Lloyd RS, Burk RF (Feb 1993). "Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA". Proc Natl Acad Sci U S A. 90 (2): 537–41. doi:10.1073/pnas.90.2.537. PMC 45698. PMID 8421687.
6. "Entrez Gene: SEPP1 selenoprotein P, plasma, 1".

Further reading

• Burk RF, Hill KE (1994). "Selenoprotein P. A selenium-rich extracellular glycoprotein". J. Nutr. 124 (10): 1891–7. doi:10.1093/jn/124.10.1891. PMID 7931697.
• Mostert V (2000). "Selenoprotein P: properties, functions, and regulation". Arch. Biochem. Biophys. 376 (2): 433–8. doi:10.1006/abbi.2000.1735. PMID 10775431.
• Hill KE, Lloyd RS, Yang JG, et al. (1991). "The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame". J. Biol. Chem. 266 (16): 10050–3. PMID 2037562.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Akesson B, Bellew T, Burk RF (1994). "Purification of selenoprotein P from human plasma". Biochim. Biophys. Acta. 1204 (2): 243–9. doi:10.1016/0167-4838(94)90014-0. PMID 8142465.
• Hill KE, Dasouki M, Phillips JA, Burk RF (1997). "Human selenoprotein P gene maps to 5q31". Genomics. 36 (3): 550–1. doi:10.1006/geno.1996.0505. PMID 8884283.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Mostert V, Lombeck I, Abel J (1998). "A novel method for the purification of selenoprotein P from human plasma". Arch. Biochem. Biophys. 357 (2): 326–30. doi:10.1006/abbi.1998.0809. PMID 9735174.
• Saito Y, Hayashi T, Tanaka A, et al. (1999). "Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein p". J. Biol. Chem. 274 (5): 2866–71. doi:10.1074/jbc.274.5.2866. PMID 9915822.
• Koyama H, Omura K, Ejima A, et al. (1999). "Separation of selenium-containing proteins in human and mouse plasma using tandem high-performance liquid chromatography columns coupled with inductively coupled plasma-mass spectrometry". Anal. Biochem. 267 (1): 84–91. doi:10.1006/abio.1998.2949. PMID 9918658.
• Arteel GE, Franken S, Kappler J, Sies H (2000). "Binding of selenoprotein P to heparin: characterization with surface plasmon resonance". Biol. Chem. 381 (3): 265–8. doi:10.1515/BC.2000.034. PMID 10782998. S2CID 36448244.
• Hondal RJ, Ma S, Caprioli RM, et al. (2001). "Heparin-binding histidine and lysine residues of rat selenoprotein P". J. Biol. Chem. 276 (19): 15823–31. doi:10.1074/jbc.M010405200. PMID 11278668.
• Nishimura K, Matsumiya K, Tsujimura A, et al. (2001). "Association of selenoprotein P with testosterone production in cultured Leydig cells". Arch. Androl. 47 (1): 67–76. doi:10.1080/01485010152104026. PMID 11442337.
• Al-Taie OH, Seufert J, Mörk H, et al. (2003). "A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency". Eur. J. Hum. Genet. 10 (9): 499–504. doi:10.1038/sj.ejhg.5200811. PMID 12173025.
• Saito Y, Takahashi K (2003). "Characterization of selenoprotein P as a selenium supply protein". Eur. J. Biochem. 269 (22): 5746–51. doi:10.1046/j.1432-1033.2002.03298.x. PMID 12423375.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.