SENP7

Sentrin-specific protease 7 is an enzyme that in humans is encoded by the SENP7 gene.[5][6][7]

SENP7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EAY
Identifiers
Aliases	SENP7, SUMO1/sentrin specific peptidase 7, SUMO specific peptidase 7
External IDs	OMIM: 612846 MGI: 1913565 HomoloGene: 10778 GeneCards: SENP7
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q12.3 Start 101,324,205 bp[1] End 101,513,241 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C1.1 Start 56,048,338 bp[2] End 56,190,012 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase activity • cysteine-type peptidase activity • GO:0001948 protein binding • hydrolase activity • G-protein coupled receptor activity • SUMO-specific endopeptidase activity Cellular component • intracellular • cell nucleus • cell membrane • cytoplasm Biological process • proteolysis • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • protein desumoylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57337	66315
Ensembl	ENSG00000138468	ENSMUSG00000052917
UniProt	Q9BQF6	Q8BUH8
RefSeq (mRNA)	NM_001077203 NM_001282801 NM_001282802 NM_001282803 NM_001282804 NM_020654	NM_001003971 NM_001003972 NM_001003973 NM_025483 NM_001304503 NM_001360073
RefSeq (protein)	NP_001070671 NP_001269730 NP_001269731 NP_001269732 NP_001269733 NP_065705	NP_001003972 NP_001003973 NP_001291432 NP_079759 NP_001347002
Location (UCSC)	Chr 3: 101.32 – 101.51 Mb	Chr 16: 56.05 – 56.19 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000138468 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052917 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
7. "Entrez Gene: SENP7 SUMO1/sentrin specific peptidase 7".

Further reading

• Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS (2007). "Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs". J. Biol. Chem. 282 (36): 26217–24. doi:10.1074/jbc.M702444200. PMID 17591783.
• Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS (2008). "Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family". Biochem. J. 409 (2): 461–9. doi:10.1042/BJ20070940. PMID 17916063. S2CID 12234952.
• Gong L, Millas S, Maul GG, Yeh ET (2000). "Differential regulation of sentrinized proteins by a novel sentrin-specific protease". J. Biol. Chem. 275 (5): 3355–9. doi:10.1074/jbc.275.5.3355. PMID 10652325.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9BQF6 (Sentrin-specific protease 7) at the PDBe-KB.