SELT

Selenoprotein T, also known as SELT, is a protein that in humans is encoded by the SELT gene.[4][5][6]

SELENOT
Identifiers
Aliases	SELENOT, SELT, selenoprotein T
External IDs	OMIM: 607912 MGI: 1916477 HomoloGene: 32304 GeneCards: SELENOT
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.1 Start 150,602,875 bp[1] End 150,630,445 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • selenium binding • thioredoxin-disulfide reductase activity • oxidoreductase activity Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • membrane • integral component of membrane Biological process • selenocysteine incorporation • positive regulation of cytosolic calcium ion concentration • positive regulation of growth hormone secretion • cellular oxidant detoxification • oxidation-reduction process • response to glucose • pancreas development • insulin secretion involved in cellular response to glucose stimulus • glucose homeostasis • cell redox homeostasis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51714	69227
Ensembl	ENSG00000198843	n/a
UniProt	P62341	P62342
RefSeq (mRNA)	NM_016275	NM_001040396
RefSeq (protein)	NP_057359	NP_001035486
Location (UCSC)	Chr 3: 150.6 – 150.63 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Gene

The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.[6]

Protein structure

Selenoprotein T contains a selenocysteine (Sec) residue at its active site.

See also

• selenoprotein

References

1. GRCh38: Ensembl release 89: ENSG00000198843 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Kryukov GV, Kryukov VM, Gladyshev VN (November 1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements". J. Biol. Chem. 274 (48): 33888–97. doi:10.1074/jbc.274.48.33888. PMID 10567350.
5. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–43. doi:10.1126/science.1083516. PMID 12775843. S2CID 10363908.
6. "Entrez Gene: SELT selenoprotein T".

Further reading

• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.