SCP2

Non-specific lipid-transfer protein also known as sterol carrier protein 2 (SCP-2) or propanoyl-CoA C-acyltransferase is a protein that in humans is encoded by the SCP2 gene.[5][6]

SCP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSCP2, NLTP, NSL-TP, SCP-2, SCP-CHI, SCP-X, SCPX, sterol carrier protein 2
External IDsOMIM: 184755 MGI: 98254 HomoloGene: 37717 GeneCards: SCP2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p32.3Start52,927,276 bp[1]
End53,051,698 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

6342

20280

Ensembl

ENSG00000116171

ENSMUSG00000028603

UniProt

P22307

P32020

RefSeq (mRNA)

NM_011327

RefSeq (protein)

NP_035457

Location (UCSC)Chr 1: 52.93 – 53.05 MbChr 4: 108.04 – 108.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.[7]

Clinical significance

This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis.[7]

Interactions

SCP2 has been shown to interact with Caveolin 1[8] and peroxisomal receptor PEX5.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000116171 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028603 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yamamoto R, Kallen CB, Babalola GO, Rennert H, Billheimer JT, Strauss JF (January 1991). "Cloning and expression of a cDNA encoding human sterol carrier protein 2". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 463–7. Bibcode:1991PNAS...88..463Y. doi:10.1073/pnas.88.2.463. PMC 50831. PMID 1703300.
  6. He Z, Yamamoto R, Furth EE, Schantz LJ, Naylor SL, George H, Billheimer JT, Strauss JF (October 1991). "cDNAs encoding members of a family of proteins related to human sterol carrier protein 2 and assignment of the gene to human chromosome 1 p21----pter". DNA Cell Biol. 10 (8): 559–69. doi:10.1089/dna.1991.10.559. PMID 1718316.
  7. "Entrez Gene: SCP2 sterol carrier protein 2".
  8. Zhou M, Parr RD, Petrescu AD, Payne HR, Atshaves BP, Kier AB, Ball JM, Schroeder F (June 2004). "Sterol carrier protein-2 directly interacts with caveolin-1 in vitro and in vivo". Biochemistry. 43 (23): 7288–306. doi:10.1021/bi035914n. PMID 15182174.
  9. Stanley WA, Filipp FV, Kursula P, Schüller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M (December 2006). "Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p". Mol. Cell. 24 (5): 653–63. doi:10.1016/j.molcel.2006.10.024. PMC 5030714. PMID 17157249.

Further reading


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