RPE (gene)

Ribulose-phosphate 3-epimerase is an enzyme that in humans is encoded by the RPE gene.[5]

RPE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OVQ, 3OVR, 3OVP, 3QC3
Identifiers
Aliases	RPE, RPE2-1, ribulose-5-phosphate-3-epimerase
External IDs	OMIM: 180480 MGI: 1913896 HomoloGene: 12005 GeneCards: RPE
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q34 Start 210,002,565 bp[1] End 210,022,260 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C3 Start 66,700,831 bp[2] End 66,719,805 bp[2]
Gene ontology Molecular function • racemase and epimerase activity, acting on carbohydrates and derivatives • ribulose-phosphate 3-epimerase activity • catalytic activity • isomerase activity • protein homodimerization activity • metal ion binding • identical protein binding Cellular component • cytosol • extracellular exosome Biological process • pentose catabolic process • pentose phosphate pathway • metabolism • pentose-phosphate shunt, non-oxidative branch • cellular carbohydrate metabolic process • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6120	66646
Ensembl	ENSG00000197713	ENSMUSG00000026005
UniProt	Q96AT9	Q8VEE0
RefSeq (mRNA)	NM_001278282 NM_001278283 NM_001278285 NM_001278286 NM_001278288 NM_001278289 NM_006916 NM_199229 NM_001318926 NM_001318927 NM_001318928 NM_001318929 NM_001318930 NM_001318931	NM_025683 NM_001310642 NM_001310643 NM_001310644
RefSeq (protein)	NP_001265211 NP_001265212 NP_001265214 NP_001265215 NP_001265217 NP_001265218 NP_001305855 NP_001305856 NP_001305857 NP_001305858 NP_001305859 NP_001305860 NP_008847 NP_954699	NP_001297571 NP_001297572 NP_001297573 NP_079959
Location (UCSC)	Chr 2: 210 – 210.02 Mb	Chr 1: 66.7 – 66.72 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000197713 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026005 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RPE ribulose-5-phosphate-3-epimerase".

Further reading

• Boss GR, Pilz RB (1985). "Phosphoribosylpyrophosphate synthesis from glucose decreases during amino acid starvation of human lymphoblasts". J. Biol. Chem. 260 (10): 6054–9. PMID 2581946.
• Miyazaki K, Yamanaka T, Ogasawara N (1989). "Interstitial deletion 2q32.1----q34 in a child with half normal activity of ribulose 5-phosphate 3-epimerase (RPE)". J. Med. Genet. 25 (12): 850–1. doi:10.1136/jmg.25.12.850. PMC 1051616. PMID 3236368.
• Dallapiccola B, Novelli G, Giannotti A (1988). "Deletion 2q31.3----2q33.3: gene dosage effect of ribulose 5-phosphate 3-epimerase". Hum. Genet. 79 (1): 92. doi:10.1007/BF00291721. PMID 3366467. S2CID 12134011.
• Spencer N, Hopkinson DA (1980). "Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE)". Ann. Hum. Genet. 43 (4): 335–42. doi:10.1111/j.1469-1809.1980.tb01567.x. PMID 7396409. S2CID 24547339.
• Stanchi F, Bertocco E, Toppo S, et al. (2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Krull M, Brosius J, Schmitz J (2005). "Alu-SINE exonization: en route to protein-coding function". Mol. Biol. Evol. 22 (8): 1702–11. doi:10.1093/molbev/msi164. PMID 15901843.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.