RNASE6

Ribonuclease A family member k6 is a protein that in humans is encoded by the RNASE6 gene. [5]

RNASE6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4X09
Identifiers
Aliases	RNASE6, RAD1, RNS6, RNasek6, ribonuclease A family member k6
External IDs	OMIM: 601981 MGI: 1925666 HomoloGene: 4102 GeneCards: RNASE6
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 20,781,268 bp[1] End 20,782,467 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 51,123,908 bp[2] End 51,132,187 bp[2]
Gene ontology Molecular function • nuclease activity • endonuclease activity • hydrolase activity • nucleic acid binding • ribonuclease activity Cellular component • extracellular region • extracellular • intracellular • cytoplasmic vesicle • lysosome Biological process • defense response • RNA catabolic process • antimicrobial humoral response • antibacterial humoral response • innate immune system • defense response to virus • antimicrobial humoral immune response mediated by antimicrobial peptide • RNA phosphodiester bond hydrolysis • defense response to bacterium • nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6039	78416
Ensembl	ENSG00000169413	ENSMUSG00000021880
UniProt	Q93091 Q6IB39	Q9D244
RefSeq (mRNA)	NM_005615	NM_030098 NM_001360117
RefSeq (protein)	NP_005606 NP_005606.1	NP_084374 NP_001347046
Location (UCSC)	Chr 14: 20.78 – 20.78 Mb	Chr 14: 51.12 – 51.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014].

References

1. GRCh38: Ensembl release 89: ENSG00000169413 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021880 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Ribonuclease A family member k6". Retrieved 2018-02-21.

Further reading

• Becknell B, Eichler TE, Beceiro S, Li B, Easterling RS, Carpenter AR, James CL, McHugh KM, Hains DS, Partida-Sanchez S, Spencer JD (January 2015). "Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract". Kidney Int. 87 (1): 151–61. doi:10.1038/ki.2014.268. PMC 4281292. PMID 25075772.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.