RIOX2

Ribosomal oxygenase 2 is a protein that in humans is encoded by the RIOX2 gene.[5][6]

RIOX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XDV, 4BU2, 4BXF
Identifiers
Aliases	RIOX2, MDIG, MINA53, NO52, ROX, MINA, MYC-induced nuclear antigen, MYC induced nuclear antigen, ribosomal oxygenase 2, JMJD10
External IDs	OMIM: 612049 MGI: 1914264 HomoloGene: 12071 GeneCards: RIOX2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q11.2 Start 97,941,818 bp[1] End 97,972,457 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C1.3 Start 59,471,775 bp[2] End 59,492,461 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity • dioxygenase activity • metal ion binding • histone demethylase activity • identical protein binding • histone demethylase activity (H3-K4 specific) • histone demethylase activity (H3-K36 specific) • GO:0001106 transcription corepressor activity Cellular component • nucleolus • transcription regulator complex • cell nucleus • nucleoplasm • cytosol Biological process • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • oxidation-reduction process • transcription, DNA-templated • negative regulation of transcription, DNA-templated • histone demethylation • chromatin remodeling • peptidyl-arginine hydroxylation • histone H3-K4 demethylation • ribosome biogenesis • histone H3-K36 demethylation • negative regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84864	67014
Ensembl	ENSG00000170854	ENSMUSG00000022724
UniProt	Q8IUF8	Q8CD15
RefSeq (mRNA)	NM_001042533 NM_001261829 NM_032778 NM_153182	NM_025910
RefSeq (protein)	NP_001035998 NP_001248758 NP_116167 NP_694822	NP_080186
Location (UCSC)	Chr 3: 97.94 – 97.97 Mb	Chr 16: 59.47 – 59.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000170854 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022724 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tsuneoka M, Koda Y, Soejima M, Teye K, Kimura H (Sep 2002). "A novel myc target gene, mina53, that is involved in cell proliferation". J Biol Chem. 277 (38): 35450–9. doi:10.1074/jbc.M204458200. PMID 12091391.
6. "Entrez Gene: MINA MYC induced nuclear antigen".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Teye K, Tsuneoka M, Arima N, et al. (2004). "Increased Expression of a Myc Target Gene Mina53 in Human Colon Cancer". Am. J. Pathol. 164 (1): 205–16. doi:10.1016/S0002-9440(10)63111-2. PMC 1602225. PMID 14695334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Eilbracht J, Reichenzeller M, Hergt M, et al. (2004). "NO66, a Highly Conserved Dual Location Protein in the Nucleolus and in a Special Type of Synchronously Replicating Chromatin". Mol. Biol. Cell. 15 (4): 1816–32. doi:10.1091/mbc.E03-08-0623. PMC 379278. PMID 14742713.
• Tsuneoka M, Fujita H, Arima N, et al. (2005). "Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma". Clin. Cancer Res. 10 (21): 7347–56. doi:10.1158/1078-0432.CCR-03-0543. PMID 15534111.
• Eilbracht J, Kneissel S, Hofmann A, Schmidt-Zachmann MS (2005). "Protein NO52--a constitutive nucleolar component sharing high sequence homologies to protein NO66". Eur. J. Cell Biol. 84 (2–3): 279–94. doi:10.1016/j.ejcb.2004.12.022. PMID 15819408.
• Zhang Y, Lu Y, Yuan BZ, et al. (2005). "The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer". Oncogene. 24 (31): 4873–82. doi:10.1038/sj.onc.1208668. PMID 15897898.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Teye K, Arima N, Nakamura Y, et al. (2007). "Expression of Myc target gene mina53 in subtypes of human lymphoma". Oncol. Rep. 18 (4): 841–8. doi:10.3892/or.18.4.841. PMID 17786344.
• Ishizaki H, Yano H, Tsuneoka M, et al. (2007). "Overexpression of the myc target gene Mina53 in advanced renal cell carcinoma". Pathol. Int. 57 (10): 672–80. doi:10.1111/j.1440-1827.2007.02156.x. PMID 17803656. S2CID 20991987.