RGS11

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.[5][6]

RGS11
Identifiers
Aliases	RGS11, RS11, regulator of G-protein signaling 11, regulator of G protein signaling 11
External IDs	OMIM: 603895 MGI: 1354739 HomoloGene: 77719 GeneCards: RGS11
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 268,301 bp[1] End 275,980 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 26,202,951 bp[2] End 26,211,324 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein beta-subunit binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • GTPase activity Cellular component • cytoplasm • cell membrane • macromolecular complex • intracellular Biological process • G-protein coupled receptor signaling pathway • negative regulation of signal transduction • GO:0007243 intracellular signal transduction • regulation of G-protein coupled receptor protein signaling pathway • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8786	50782
Ensembl	ENSG00000076344	ENSMUSG00000024186
UniProt	O94810	Q9Z2H1
RefSeq (mRNA)	NM_001286485 NM_001286486 NM_003834 NM_183337	NM_001081069
RefSeq (protein)	NP_001273414 NP_001273415 NP_003825 NP_899180	NP_001074538
Location (UCSC)	Chr 16: 0.27 – 0.28 Mb	Chr 17: 26.2 – 26.21 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000076344 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024186 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc Natl Acad Sci U S A. 95 (22): 13307–12. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.
6. "Entrez Gene: RGS11 regulator of G-protein signalling 11".

Further reading

• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16" (PDF). Nature. 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553. S2CID 4362044.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
• Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997). "Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain". J. Neurosci. 17 (20): 8024–37. doi:10.1523/JNEUROSCI.17-20-08024.1997. PMC 6793903. PMID 9315921.