REG3G

Regenerating islet-derived protein 3 gamma (also Regenerating islet-derived protein III-gamma) is a protein that in humans is encoded by the REG3G gene.[5][6][7][8]

REG3G
Identifiers
Aliases	REG3G, LPPM429, PAP IB, PAP-1B, PAP1B, PAPIB, REG III, REG-III, UNQ429, regenerating family member 3 gamma
External IDs	OMIM: 609933 MGI: 109406 HomoloGene: 128216 GeneCards: REG3G
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p12 Start 79,025,686 bp[1] End 79,028,505 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 78,466,269 bp[2] End 78,468,872 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • carbohydrate binding • peptidoglycan binding • oligosaccharide binding • transmembrane signaling receptor activity Cellular component • cytoplasm • extracellular region • extracellular Biological process • positive regulation of wound healing • positive regulation of keratinocyte proliferation • negative regulation of keratinocyte differentiation • inflammatory response • acute-phase response • MyD88-dependent toll-like receptor signaling pathway • defense response to Gram-positive bacterium • antimicrobial humoral response • antimicrobial humoral immune response mediated by antimicrobial peptide • positive regulation of cell proliferation • response to peptide hormone • cell wall disruption in other organism Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	130120	19695
Ensembl	ENSG00000143954	ENSMUSG00000030017
UniProt	Q6UW15	O09049
RefSeq (mRNA)	NM_001008387 NM_001270040 NM_198448	NM_011260
RefSeq (protein)	NP_001008388 NP_001256969 NP_940850	NP_035390
Location (UCSC)	Chr 2: 79.03 – 79.03 Mb	Chr 6: 78.47 – 78.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Intestinal paneth cells produce REG3G (or REG3 gamma) via stimulation of toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs). REG3 gamma specifically targets Gram-positive bacteria because it binds to their surface peptidoglycan layer. It is one of several antimicrobial peptides produced by paneth cells.[9]

Notes and references

1. GRCh38: Ensembl release 89: ENSG00000143954 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030017 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
6. Nata K, Liu Y, Xu L, Ikeda T, Akiyama T, Noguchi N, Kawaguchi S, Yamauchi A, Takahashi I, Shervani NJ, Onogawa T, Takasawa S, Okamoto H (September 2004). "Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III". Gene. 340 (1): 161–70. doi:10.1016/j.gene.2004.06.010. PMID 15556304.
7. Laurine E, Manival X, Montgelard C, Bideau C, Bergé-Lefranc JL, Erard M, Verdier JM (March 2005). "PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication" (PDF). Biochim. Biophys. Acta. 1727 (3): 177–87. doi:10.1016/j.bbaexp.2005.01.011. PMID 15777617.
8. "Entrez Gene: REG3G regenerating islet-derived 3 gamma".
9. Abreu MT (February 2010). "Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function". Nat. Rev. Immunol. 10 (2): 131–44. doi:10.1038/nri2707. PMID 20098461. S2CID 21789611.

Bibliography

• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Laurine E, Manival X, Montgelard C, et al. (2005). "PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication". Biochim. Biophys. Acta. 1727 (3): 177–87. doi:10.1016/j.bbaexp.2005.01.011. PMID 15777617.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brandl K, Plitas G, Schnabl B, DeMatteo RP, Pamer EG (2007). "MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection". J. Exp. Med. 204 (8): 900–1891. doi:10.1084/jem.20070563. PMC 2118673. PMID 17635956.