RDH14

Retinol dehydrogenase 14 is an enzyme that in humans is encoded by the RDH14 gene.[5][6][7]

RDH14
Identifiers
Aliases	RDH14, PAN2, SDR7C4, retinol dehydrogenase 14 (all-trans/9-cis/11-cis), retinol dehydrogenase 14
External IDs	OMIM: 616796 MGI: 1920402 HomoloGene: 75139 GeneCards: RDH14
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p24.2 Start 18,554,723 bp[1] End 18,560,679 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 10,390,772 bp[2] End 10,395,562 bp[2]
Gene ontology Molecular function • alcohol dehydrogenase (NADP+) activity • oxidoreductase activity • NADP-retinol dehydrogenase activity • steroid dehydrogenase activity Cellular component • lysosomal membrane • endoplasmic reticulum • mitochondrion • cell nucleus • endoplasmic reticulum membrane • membrane Biological process • retinol metabolic process • oxidation-reduction process • osteoblast differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57665	105014
Ensembl	ENSG00000240857	ENSMUSG00000020621
UniProt	Q9HBH5	Q9ERI6
RefSeq (mRNA)	NM_020905	NM_023697
RefSeq (protein)	NP_065956	NP_076186
Location (UCSC)	Chr 2: 18.55 – 18.56 Mb	Chr 12: 10.39 – 10.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000240857 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020621 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, Palczewski K (Nov 2002). "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina". J Biol Chem. 277 (47): 45537–46. doi:10.1074/jbc.M208882200. PMC 1435693. PMID 12226107.
6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
7. "Entrez Gene: RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Belyaeva OV, Kedishvili NY (2002). "Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues". FEBS Lett. 531 (3): 489–93. doi:10.1016/S0014-5793(02)03588-3. PMID 12435598. S2CID 22343979.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.