RAB11FIP4

Rab11 family-interacting protein 4 is a protein that in humans is encoded by the RAB11FIP4 gene.[5][6][7]

RAB11FIP4
Identifiers
Aliases	RAB11FIP4, RAB11-FIP4, RAB11 family interacting protein 4, FIP4-Rab11
External IDs	OMIM: 611999 MGI: 2442920 HomoloGene: 8803 GeneCards: RAB11FIP4
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 31,391,675 bp[1] End 31,538,211 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 46.88 cM Start 79,591,212 bp[2] End 79,698,023 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • protein homodimerization activity • metal ion binding • Rab GTPase binding • GO:0001948 protein binding • ADP-ribosylation factor binding Cellular component • cytoplasm • endosome • membrane • endocytic vesicle • spindle • microtubule organizing center • recycling endosome membrane • midbody • perinuclear region of cytoplasm • cleavage furrow • cytoskeleton • cytoplasmic vesicle • extracellular • intracellular membrane-bounded organelle • centrosome Biological process • positive regulation of G1 to G0 transition • cytokinesis • GO:0022415 viral process • neural retina development • transport • endocytic recycling • regulation of cytokinesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84440	268451
Ensembl	ENSG00000131242	ENSMUSG00000017639
UniProt	Q86YS3	Q8BQP8
RefSeq (mRNA)	NM_001303542 NM_001346747 NM_001346748 NM_001346749 NM_032932	NM_175543
RefSeq (protein)	NP_001290471 NP_001333676 NP_001333677 NP_001333678 NP_116321	NP_780752
Location (UCSC)	Chr 17: 31.39 – 31.54 Mb	Chr 11: 79.59 – 79.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RAB11FIP4 has been shown to interact with RAB11A.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000131242 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017639 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
6. Jenne DE, Tinschert S, Reimann H, Lasinger W, Thiel G, Hameister H, Kehrer-Sawatzki H (Aug 2001). "Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions". Am J Hum Genet. 69 (3): 516–527. doi:10.1086/323043. PMC 1235482. PMID 11468690.
7. "Entrez Gene: RAB11FIP4 RAB11 family interacting protein 4 (class II)".
8. Wallace, Deborah M E; Lindsay Andrew J; Hendrick Alan G; McCaffrey Mary W (Dec 2002). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. United States. 299 (5): 770–779. doi:10.1016/S0006-291X(02)02720-1. ISSN 0006-291X. PMID 12470645.

Further reading

• Jenne DE, Tinschert S, Stegmann E, et al. (2000). "A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions". Genomics. 66 (1): 93–97. doi:10.1006/geno.2000.6179. PMID 10843809.
• Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2003). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. 299 (5): 770–779. doi:10.1016/S0006-291X(02)02720-1. PMID 12470645.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jenne DE, Tinschert S, Dorschner MO, et al. (2003). "Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse". Genes Chromosomes Cancer. 37 (2): 111–120. doi:10.1002/gcc.10206. PMID 12696059. S2CID 37232718.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fielding AB, Schonteich E, Matheson J, et al. (2006). "Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis". EMBO J. 24 (19): 3389–3399. doi:10.1038/sj.emboj.7600803. PMC 1276165. PMID 16148947.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–965. doi:10.1038/ng2083. PMID 17632510. S2CID 35797973.