Proser1

PROSER1 is a protein that in humans is encoded by the PROSER1 gene.[2]

Proser1
Identifiers
Aliases2810046L04Rik9330161F11proline and serine rich 1
External IDsHomoloGene: 13463 GeneCards:
Gene location (Human)
Chr.Chromosome 3 (human)
Band3|3 CStart53,463,666 bp
End53,481,755 bp
Orthologs
SpeciesHumanMouse
Entrez

212127

n/a

Ensembl

ENSMUSG00000049504

n/a

UniProt

Q5PRE5

n/a

RefSeq (mRNA)

NM_173382

n/a

RefSeq (protein)

NP_775558

n/a

Location (UCSC)Chr 3: 53.46 – 53.48 Mbn/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Nomenclature

PROSER1 has several aliases: C13orf23, KIAA2032, and proline and serine-rich protein 1.[3] [4]

Gene
Location of PROSER1 on chromosome 13.

Location

PROSER1 is located on the negative (reverse) strand of chromosome 13 at position 13q13.3. It spans from 39,009,865 base pairs from the pter to 39,038,095 bp from the pter, with a size of 28,231 bases.[5] PROSER1 has a total of 13 exons in its primary unspliced transcript mRNA of 5,185 bp. There are 2 isoforms of PROSER1, both within the 5,000 bp range.[6]

Gene neighborhood

Genes STOML3 and NHLRC3 neighbor PROSER1 on chromosome 13.[7]

Tissue distribution
Diagram depicting the level of expression of PROSER1 in various parts of the human body.

Expressed Sequence Tag mapping of PROSER1 expression shows that it has particularly high expression in lymph, embryonic tissue, thymus, and uterus sites. It has moderate expression in testis, larynx, nerve, blood, and adipose tissue sites.[8] According to the Human Protein Atlas, PROSER1 has general cytoplasmic expression and is expressed in all RNA tissue categories.[9]

Homology

Paralogs

PROSER1 has no paralogs.[10]

Orthologs

PROSER1 is highly conserved among mammals. It is less highly conserved, though has been found, in fish, birds, and some invertebrates. It is not expressed in bacteria, plants, or fungi.[11] Show below is table of orthologs compiled from NCBI.

Latin nameCommon nameDate of divergence (from H. sapiens)Accession numberProtein sequence lengthSequence identitySequence similarity
Homo sapiensHuman-NP_079414.3944 amino acids--
Gorilla gorillaGorilla8.9 million years agoXP_004054459994 aa99%99%
Colobus angolensis palliatus Angola colobus29.1 MYAXP_011798372947 aa97%97%
Nannospalax galiliSpalax90.9 MYAXP_008847583916 aa80%85%
Cricetulus griseusChinese Hamster90.9 MYAXP_007626898912 aa79%84%
Panthera tigris altaicaSiberian Tiger97.5 MYAXP_007097793665 aa85%89%
Acinonyx jubatusCheetah97.5 MYAXP_014926409770 aa79%83%
Tursiops truncatusCommon Bottlenose Dolphin97.5 MYAXP_0043323671064 aa77%83%
Ornithorhynchus anatinusPlatypus179.2 MYAXP_007666895888 aa69%74%
Chelonia mydasGreen Sea Turtle320.5 MYAXP_007070970936 aa75%83%
Pygoscelis adeliaeAdelie Penguin320.5 MYAXP_009318201938 aa75%83%
Calidris (philomachus) pugnaxRuff320.5 MYAXP_014821534899 aa74%83%
Chrysemys picta belliiPainted Turtle320.5 MYAXP_008175998825 aa73%82%
Aquila chrysaetos CanadensisGolden Deagle320.5 MYAXP_011579121916 aa73%81%
Alligator sinensisChinese Alligator320.5 MYAXP_014376376940 aa72%81%
Gekko japonicusJapanese Gecko320.5 MYAXP_0152818371053 aa65%75%
Python bivittatusBurmese Python320.5 MYAXP_007438154924 aa65%75%
Anolis carolinensisCarolina Anole320.5 MYAXP_008124125920 aa64%75%
Xenopus tropicalisWestern Clawed Frog355.7 MYAXP_012813331944 aa51%63%
Lepisosteus oculatusSpotted Gar429.6 MYAXP_015197497885 aa47%58%
Callorhinchus miliiAustralian Ghost Shark482.9 MYAXP_007889503965 aa64%75%

Protein

General properties

The translated PROSER1 protein is 944 amino acids long. Its predicted molecular weight is 95.7 kdal.[12] PROSER1 has an isoelectric point of 9.[13] It is predicted to be localized to the nucleus.[14]

Composition

The sequence is rich in proline and serine and not particularly low in any other amino acids.

Domains

PROSER1 contains one domain of unknown function, DUF 4476, part of pfam14771. The DUF spans from amino acids 26 to 121. The molecular weight of DUF 4476 is 11.1 kdal.

Detailed location of DUF 4476 on PROSER1.

Secondary structure

PROSER1 is composed primarily of alpha helices, beta sheets, and coils. The protein is largely coiled. The DUF is composed mainly of alpha helices and coils. It has slightly fewer beta sheets compared to the protein as a whole.[15]

References
  1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. "GeneCards". Human Gene Database.
  3. "BioCompare". BioCompare.
  4. "Ensembl". Ensembl.
  5. "GeneCards". Human Gene Database.
  6. "NCBI Gene". NCBI.
  7. "NCBI Gene". NCBI.
  8. "Uniprot". Uniprot.
  9. "Tissue Atlas". The Human Protein Atlas.
  10. "Ensembl". Ensembl.
  11. "Ensembl". Ensembl.
  12. "Uniprot". Uniprot.
  13. "Expasy". Expasy.
  14. "PSORT II Prediction". PSORT II.
  15. "SDSC Biology Workbench". SDSC.
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