Prophage Hp1 holin family

The Prophage Hp1 Hol (Hp1Hol) Family (TC# 1.E.46) consists of a single putative holin (TC# 1.E.46.1.1) of 69 amino acyl residues in length, exhibiting what appears to be a single transmembrane segment (TMS). It is derived from the firmicute, Clostridium hathewayi DSM 13479. This protein is functionally uncharacterized and does not appear to be homologous to other holins. It does, however, show 31% identity to a heavy metal transporter from Dethiosulfovibrio peptidovorans.[1][2]

See also

• Holin
• Lysin
• Transporter Classification Database

Further reading

• Reddy, Bhaskara L.; Saier, Jr.; Milton, H. (2013). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059. PMID 23856191.
• Saier, Milton H.; Reddy, Bhaskara L. (2015). "Holins in Bacteria, Eukaryotes, and Archaea: Multifunctional Xenologues with Potential Biotechnological and Biomedical Applications". Journal of Bacteriology. 197 (1): 7–17. doi:10.1128/JB.02046-14. PMC 4288690. PMID 25157079.
• Wang, I. N.; Smith, D. L.; Young, R. (2000). "Holins: the protein clocks of bacteriophage infections". Annual Review of Microbiology. 54: 799–825. doi:10.1146/annurev.micro.54.1.799. PMID 11018145.
• Young, R.; Bläsi, U. (1995). "Holins: form and function in bacteriophage lysis". FEMS Microbiology Reviews. 17 (1–2): 191–205. doi:10.1111/j.1574-6976.1995.tb00202.x. PMID 7669346.

References

1. "1.E.46 The Prophage Hp1 Hol (Hp1Hol) Family". TCDB. Retrieved 2016-03-29.
2. "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2016-03-29.

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