Proctosedyl

Proctosedyl is the brand name for a family of two products with identical active ingredients designed to treat a variety of proctological disorders. One is a topical ointment, the other a rectal suppository. In the United Kingdom both products are contract manufactured by Patheon Limited on behalf of the Sanofi-Aventis group.[1][2] Manufacture and distribution is provided by Sanofi Aventis subsidiaries[3] Hoechst and Hoechst Marion Roussel in other territories worldwide.[4]

Application

Both the yellowish-white, translucent, greasy ointment[1] and the smooth, off-white suppositories[2] are formulated for the relief of chronic pruritus ani (otherwise known anal itching or anusitis)[1][2][5] and the treatment of pain, irritation, discharge and itching associated with haemorrhoids (otherwise known as piles).[1][2][5] However both products are also used to provide pain relief in the treatment of anal fissure,[6][7][8] for patients undergoing haemorrhoidectomy, (pre and post-operative),[8] in the relief of post-partum (otherwise known as post-natal) haemorrhoidal conditions,[8][9] and in the treatment of non-infective proctitis.[8]

Active ingredients

Both preparations contain:

Preparations in some territories may also contain:

References
  1. "Patient Information Leaflets Online: Proctosedyl Ointment: PL 04425/0207". Retrieved 2009-01-21.
  2. "Patient Information Leaflets Online: Proctosedyl Suppositories: PL 04425/0208". Retrieved 2009-01-21.
  3. "Sanofi Aventis: Hoechst Home Page". Retrieved 2009-01-22.
  4. "The South African Medical Formulary: C05A Antihaemorrhoidals for topical use". Archived from the original on 2003-03-30. Retrieved 2009-01-22.
  5. "NetDoctor: Proctosedyl ointment/suppositories". Retrieved 2009-01-21.
  6. Maan MS, Mishra R, Thomas S, Hadke NS (2004). "Randomized, double-blind trial comparing topical nitroglycerine with xylocaine and Proctosedyl in idiopathic chronic anal fissure". Indian Journal of Gastroenterology. 23 (3): 91–3. PMID 15250565.
  7. "A general practitioner study to evaluate the efficacy of 'Proctosedyl' ointment in the treatment of acute fissure-in-ano". The British Journal of Clinical Practice. 24 (7): 289–91. July 1970. PMID 4919315.
  8. "Medsafe: Information for Health Professionals: Proctosedyl". Archived from the original on October 22, 2008. Retrieved 2009-01-21.
  9. Damianov L, Katsarova M (1993). "[Our experience in using the preparation Proctosedyl from the Roussel firm in pregnant women with hemorrhoids]". Akusherstvo I Ginekologii͡a (in Bulgarian). 32 (3): 71. PMID 8037333.
  10. Larsen PO (September 1992). "[The Danish fund for basic research--a new cigar-box]". Ugeskrift for Laeger (in Danish). 154 (39): 2657. PMID 1413190.
  11. Duncan SH, Leitch EC, Stanley KN, et al. (May 2004). "Effects of esculin and esculetin on the survival of Escherichia coli O157 in human faecal slurries, continuous-flow simulations of the rumen and colon and in calves". The British Journal of Nutrition. 91 (5): 749–55. doi:10.1079/BJN20041101. PMID 15137927.
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