Polyozellin

Polyozellin is a chemical which occurs in the mushroom Polyozellus multiplex. It inhibits prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.[1] Structurally related dibenzofuranyl derivatives of polyozellin are known as kynapcins.[2]

Polyozellin

Names
IUPAC name 6,12-Diacetoxy-2,3,8,9-tetrahydroxybenzo[1,2-b;4,5-b']bisbenzofuran
Identifiers
CAS Number	197703-46-1
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL458248
ChemSpider	338925
PubChem CID	382514
CompTox Dashboard (EPA)	DTXSID30327611
InChI InChI=1S/C22H14O10/c1-7(23)29-19-17-9-3-11(25)13(27)5-15(9)32-22(17)20(30-8(2)24)18-10-4-12(26)14(28)6-16(10)31-21(18)19/h3-6,25-28H,1-2H3 Key: CCNILPFRYYKQOP-UHFFFAOYSA-N InChI=1/C22H14O10/c1-7(23)29-19-17-9-3-11(25)13(27)5-15(9)32-22(17)20(30-8(2)24)18-10-4-12(26)14(28)6-16(10)31-21(18)19/h3-6,25-28H,1-2H3 Key: CCNILPFRYYKQOP-UHFFFAOYAD
SMILES CC(=O)OC1=C2C(=C(C3=C1C4=CC(=C(C=C4O3)O)O)OC(=O)C)C5=CC(=C(C=C5O2)O)O
Properties
Chemical formula	C22H14O10
Molar mass	438.344 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

References

1. Hwang JS, Song KS, Kim WG, Lee TH, Koshino H, Yoo ID (1997). "Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex". The Journal of Antibiotics. 50 (9): 773–77. doi:10.7164/antibiotics.50.773. PMID 9360624.
2. Kim SI, Park IH, Song KS (2002). "kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus multiplex". The Journal of Antibiotics. 55 (7): 623–28. doi:10.7164/antibiotics.55.623. PMID 12243451.