Plasma cell granuloma

Plasma cell granuloma is a lesional pattern of inflammatory pseudotumour, different from the "inflammatory myofibroblastic tumor" pattern.

It is linked to IgG4-related disease.[1]

Pathology

Histologically, the lesions consisted of a proliferation of mature plasma cells and reticulo-endothelial cells supported by a stroma of granulation tissue, with varying degrees of myxoid change or collagenization. Angioinvasion within the lesion is observed in 50% of cases.[2]

Immunohistochemical staining reveals the IgG-predominant polyclonal nature of the plasma cells, indicating a reactive inflammatory process rather than a neoplastic one.

Electron microscopy confirms the benign nature of the plasma cells with fibroblast and myofibroblast proliferation admixed with that of other inflammatory cells.

Localization

See also

References
  1. Dias, O. M.; Kawassaki Ade, M; Haga, H; Cukier, A; Carvalho, C. R. (2011). "Immunoglobulin G4-related systemic sclerosing disease in a patient with sclerosing cholangitis, inflammatory pseudotumors of the lung and multiple radiological patterns: A case report". Clinics (Sao Paulo, Brazil). 66 (11): 1983–6. doi:10.1590/s1807-59322011001100021. PMC 3203974. PMID 22086532.
  2. Nonomura, A; Mizukami, Y; Matsubara, F; Shimizu, J; Oda, M; Watanabe, Y; Kamimura, R; Takashima, T; Kitagawa, M (1992). "Seven patients with plasma cell granuloma (inflammatory pseudotumor) of the lung, including two with intrabronchial growth: An immunohistochemical and electron microscopic study". Internal Medicine (Tokyo, Japan). 31 (6): 756–65. doi:10.2169/internalmedicine.31.756. PMID 1392177.
  3. Nonomura, A; Mizukami, Y; Matsubara, F; Shimizu, J; Oda, M; Watanabe, Y; Kamimura, R; Takashima, T; Kitagawa, M (1992). "Seven patients with plasma cell granuloma (inflammatory pseudotumor) of the lung, including two with intrabronchial growth: An immunohistochemical and electron microscopic study". Internal Medicine (Tokyo, Japan). 31 (6): 756–65. doi:10.2169/internalmedicine.31.756. PMID 1392177.
  4. Balachandran, A; Shivbalan, S (2004). "Plasma cell granuloma of the lung". Indian Pediatrics. 41 (3): 292–3. PMID 15064526.


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