Piperidylthiambutene

Piperidylthiambutene (Piperidinohton) is a synthetic[1] opioid analgesic drug from the thiambutene family, which has around the same potency as morphine.[2][3][4] Piperidylthiambutene is structurally distinct from fentanyl, its analogues, and other synthetic opioids previously reported.[1] If sold or obtained for the purpose of human consumption it could be considered a controlled substance analogue in some countries such as the US, Australia and New Zealand. Piperidylthiambutene has been sold as a designer drug, first appearing in late 2018.[5][6]

Piperidylthiambutene
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC17H21NS2
Molar mass303.48 g·mol−1
3D model (JSmol)
Melting point188 to 189 °C (370 to 372 °F)
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References
  1. "Piperidylthiambutene" (PDF). NMS Labs. Retrieved 2020-09-14.
  2. Adamson DW, Green AF (January 1950). "A new series of analgesics". Nature. 165 (4186): 122. Bibcode:1950Natur.165..122A. doi:10.1038/165122a0. PMID 15409854. S2CID 4190157.
  3. Adamson DW, Duffin WM, Green AF (January 1951). "Dithienylbutylamines as analgesics". Nature. 167 (4239): 153–4. Bibcode:1951Natur.167..153A. doi:10.1038/167153b0. PMID 14806409. S2CID 4280042.
  4. Green AF (March 1953). "Analgesic and other properties of 3: 3-dithienylalkenylamines". British Journal of Pharmacology and Chemotherapy. 8 (1): 2–9. doi:10.1111/j.1476-5381.1953.tb00739.x. PMC 1509239. PMID 13066683.
  5. "Analytical report Piperidylthiambutene" (PDF). European Project Response. November 2018.
  6. Vandeputte MM, Cannaert A, Stove CP. In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances. Arch Toxicol. 2020 Nov;94(11):3819-3830. doi:10.1007/s00204-020-02855-7 PMID 32734307
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