Phosphatidylcholine—dolichol O-acyltransferase
In enzymology, a phosphatidylcholine---dolichol O-acyltransferase (EC 2.3.1.83) is an enzyme that catalyzes the chemical reaction
- 3-sn-phosphatidylcholine + dolichol 1-acyl-sn-glycero-3-phosphocholine + acyldolichol
| phosphatidylcholine-dolichol O-acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.83 | ||||||||
| CAS number | 9012-30-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3-sn-phosphatidylcholine and dolichol, whereas its two products are 1-acyl-sn-glycero-3-phosphocholine and acyldolichol.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 3-sn-phosphatidylcholine:dolichol O-acyltransferase.
References
- Keenan RW, Kruczek ME (1976). "The esterification of dolichol by rat liver microsomes". Biochemistry. 15 (7): 1586–91. doi:10.1021/bi00652a032. PMID 4095.
- Radominska-Pyrek A, Chojnacki T, Zulczyk W (1979). "Acyl esters of polyprenols: specificity of microsomal transacylase for polyprenols of different chain length and saturation". Acta Biochim. Pol. 26 (1–2): 125–34. PMID 506613.
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