PRKX

Protein kinase, X-linked is a protein that in humans is encoded by the PRKX gene. [5]

PRKX
Identifiers
Aliases	PRKX, PKX1, protein kinase, X-linked, protein kinase X-linked
External IDs	OMIM: 300083 MGI: 1309999 HomoloGene: 55868 GeneCards: PRKX
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.33 Start 3,604,340 bp[1] End 3,713,649 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X B Start 77,761,411 bp[2] End 77,796,278 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • cAMP-dependent protein kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • ATP binding Cellular component • cytoplasm • cell nucleus Biological process • myeloid cell differentiation • cell differentiation • regulation of cell migration • phosphorylation • epithelial tube morphogenesis • multicellular organism development • protein phosphorylation • cell-substrate adhesion • regulation of cell adhesion • cell adhesion • peptidyl-serine phosphorylation • endothelial cell proliferation • kidney morphogenesis • angiogenesis • autophosphorylation • endothelial cell migration • regulation of epithelial cell differentiation involved in kidney development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5613	19108
Ensembl	ENSG00000183943	ENSMUSG00000035725
UniProt	P51817	Q922R0
RefSeq (mRNA)	NM_005044	NM_016979
RefSeq (protein)	NP_005035 NP_005035.1	NP_058675
Location (UCSC)	Chr X: 3.6 – 3.71 Mb	Chr X: 77.76 – 77.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y.

References

1. GRCh38: Ensembl release 89: ENSG00000183943 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035725 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Protein kinase, X-linked". Retrieved 2017-05-19.

Further reading

• Li X, Li HP, Amsler K, Hyink D, Wilson PD, Burrow CR (2002). "PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9260–5. doi:10.1073/pnas.132051799. PMC 123128. PMID 12082174.
• Li X, Burrow CR, Polgar K, Hyink DP, Gusella GL, Wilson PD (2008). "Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency" (PDF). Biochim. Biophys. Acta. 1782 (1): 1–9. doi:10.1016/j.bbadis.2007.09.003. PMID 17980165.
• Li X, Iomini C, Hyink D, Wilson PD (2011). "PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation". Dev. Biol. 356 (2): 475–85. doi:10.1016/j.ydbio.2011.05.673. PMID 21684272.
• Lin Y, Li W (2011). "MBD 4--a potential substrate for protein kinase X". Acta Biochim. Biophys. Sin. (Shanghai). 43 (11): 916–7. doi:10.1093/abbs/gmr086. PMID 21971312.
• Bender C, Ullrich A (2012). "PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines". Int. J. Cancer. 131 (2): E45–55. doi:10.1002/ijc.26486. PMID 22020623.
• Huang S, Li Q, Alberts I, Li X (2016). "PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development". J. Cell. Biochem. 117 (3): 566–73. doi:10.1002/jcb.25304. PMID 26252946.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.