PPP4R1

Serine/threonine-protein phosphatase 4 regulatory subunit 1 is an enzyme that in humans is encoded by the PPP4R1 gene.[5][6]

PPP4R1
Identifiers
Aliases	PPP4R1, MEG1, PP4(Rmeg), PP4R1, protein phosphatase 4 regulatory subunit 1
External IDs	OMIM: 604908 MGI: 1917601 HomoloGene: 81737 GeneCards: PPP4R1
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.22 Start 9,546,791 bp[1] End 9,615,240 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E1.1 Start 65,782,573 bp[2] End 65,841,926 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • phosphoprotein phosphatase activity • protein phosphatase regulator activity • protein serine/threonine phosphatase activity Cellular component • protein phosphatase 4 complex Biological process • protein phosphorylation • GO:0048552 regulation of catalytic activity • signal transduction • protein dephosphorylation • regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9989	70351
Ensembl	ENSG00000154845	ENSMUSG00000061950
UniProt	Q8TF05	Q8K2V1
RefSeq (mRNA)	NM_001042388 NM_005134 NM_001382562	NM_001114131 NM_146081
RefSeq (protein)	NP_001035847 NP_005125 NP_001369491	NP_001107603 NP_666193
Location (UCSC)	Chr 18: 9.55 – 9.62 Mb	Chr 17: 65.78 – 65.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PPP4R1 has been shown to interact with PPP4C.[7][8][9]

References

1. GRCh38: Ensembl release 89: ENSG00000154845 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061950 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kloeker S, Wadzinski BE (Feb 1999). "Purification and identification of a novel subunit of protein serine/threonine phosphatase 4". The Journal of Biological Chemistry. 274 (9): 5339–47. doi:10.1074/jbc.274.9.5339. PMID 10026142.
6. "Entrez Gene: PPP4R1 protein phosphatase 4, regulatory subunit 1".
7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
8. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
9. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E (Apr 2005). "Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4". Genes & Development. 19 (7): 827–39. doi:10.1101/gad.1286005. PMC 1074320. PMID 15805470.
• Wada T, Miyata T, Inagi R, Nangaku M, Wagatsuma M, Suzuki D, Wadzinski BE, Okubo K, Kurokawa K (Dec 2001). "Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells". Journal of the American Society of Nephrology. 12 (12): 2601–8. PMID 11729228.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.